Last reviewed · How we verify
NCT03398733: CPAP
CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease
NA trial testing continuous positive airway pressure in Rheumatic Valvular Heart Disease in 32 participants. Completed in 31 January 2020.
1 December 2019
Quick facts
| Lead sponsor | Nanjing Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 1 December 2017 |
| Primary completion | 1 December 2019 |
| Estimated completion | 31 January 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- continuous positive airway pressure
Conditions studied
- Rheumatic Valvular Heart Disease — all drugs for Rheumatic Valvular Heart Disease →
- Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
Sponsor
Nanjing Medical University
Who can join
Adults 18 to 75, any sex, with Rheumatic Valvular Heart Disease or Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The prevalence of OSA (Obstructive sleep apnea，OSA) is 2%-4% in general population and 16%-47% in surgical-heart failure patients. Our previous study found that OSA was associated with the increasing incidence of perioperative adverse events.The continuous positive airway pressure (CPAP), as the standard treatment for OSA, is extensively applied clinically. The previous study reported that postoperative AHI was reduced and SPO2 was increased by CPAP treatment. However, whether CPAP treatment can improve OSA postoperative and related adverse events or not in patients with rheumatic valvular heart diseases (RVHD) were not reported.The purpose of this study is to observe the effective of preoperative CPAP on postoperative sleep parameters and adverse events, such as AHI changes, duration of ICU stay and duration of mechanical ventilation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of 1-week preoperative auto-CPAP treatment on postoperative outcomes in patients undergoing heart valve replacement surgery: a prospective randomized controlled trial.
Su M, Lin W, Xu Q, Ni B, et al · · 2023 · PMID 37342775 · DOI 10.3389/fneur.2023.1152168
Verify or expand the search:
- PubMed search for NCT03398733
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of continuous positive airway pressure
Trials testing the same drug.
- NCT07357272 — A Cohort Study on Increasing Blood Pressure Benefits in Sleep Apnea Patients After CPAP Treatment · recruiting
- NCT06711159 — SLEEPINESS - a Search for a Biomarker of Excessive Daytime Sleepiness in Severe Obstructive Sleep Apnoea - An Explorativ · recruiting
- NCT06508190 — Free Walking Exercise in Obstructive Sleep Apnea Patients With Non-alcoholic Fatty Liver · NA · recruiting
- NCT04513483 — CPAP in AF Patients With OSA · NA · completed
- NCT03839654 — Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement · NA · unknown
Other Nanjing Medical University trials
Trials by the same sponsor.
- NCT07382375 — AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection · NA · not yet recruiting
- NCT07494474 — Risk Assessment of Pancreatic Islet Autoimmunity in Patients With AITD · not yet recruiting
- NCT07482774 — Tumor Microenvironment Changes After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma · not yet recruiting
- NCT07348328 — Vitamin B Supplementation for Patients Undergoing Cardiovascular Surgery · NA · not yet recruiting
- NCT07258394 — Clinical Study for Dimethyl Fumarate in Preserving Islet β-Cell Function in Type 1 Diabetes Mellitus · Phase 3 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03398733 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nanjing Medical University
- Last refreshed: 25 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03398733.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing