NCT03394859 (eMERGE) is a clinical trial in Cardiac Disease, sponsored by Vanderbilt University Medical Center.

Who is sponsoring NCT03394859?

NCT03394859 is sponsored by Vanderbilt University Medical Center.

What condition does NCT03394859 study?

NCT03394859 studies Cardiac Disease, Cancer, Hypercholesterolemia, Diabetes, Kidney Diseases, Neuromuscular Diseases.

Is NCT03394859 still recruiting?

NCT03394859 is currently completed. Last updated 28 May 2020.

Last reviewed 2020-05-28 · How we verify

NCT03394859: eMERGE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Electronic Medical Records and Genomics (eMERGE) Phase III

Completed Last updated 28 May 2020

What this trial tests

trial in Cardiac Disease in 25,380 participants. Completed in 1 April 2020.

Timeline

1 September 2015

Primary endpoint
1 April 2020

1 April 2020

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	25,380
Start date	1 September 2015
Primary completion	1 April 2020
Estimated completion	1 April 2020

Conditions studied

Cardiac Disease — all drugs for Cardiac Disease →
Cancer — all drugs for Cancer →
Hypercholesterolemia — all drugs for Hypercholesterolemia →
Diabetes — all drugs for Diabetes →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 1 Day to 120, any sex, with Cardiac Disease or Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes. The genetic results will be returned to participants and outcomes tracked through the electronic health records.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study.
Glazer AM, Davogustto G, Shaffer CM, Vanoye CG, et al · · 2022 · cited 43× · PMID 34930020 · DOI 10.1161/circulationaha.121.055562
Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.
Ferar K, Hall TO, Crawford DC, Rowley R, et al · · 2023 · cited 2× · PMID 37898691 · DOI 10.1038/s41598-023-45649-4
Practice Patterns After Return of Rare Variants Associated With Cardiomyopathy in the Electronic Medical Records and Genomics Network.
Khan SS, Hoell C, Castillo LM, Connolly JJ, et al · · 2021 · cited 2× · PMID 33951936 · DOI 10.1161/circheartfailure.120.008155

Verify or expand the search:

Other recruiting trials for Cardiac Disease

Currently open trials in the same condition.

NCT07532174 — Efferon LPS Hemoadsorption in Cardiac Surgery Patients · NA · recruiting
NCT06294119 — Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay · NA · recruiting
NCT07274436 — The Clinical Value of Deep Learning-Based Reconstruction Techniques in Cardiac MRI Scanning · recruiting
NCT07217392 — Left Bundle Branch Area Pacing (LBBAP) PMCF Study · NA · recruiting
NCT05877755 — Validation of Multi-contrast, High-resolution Cardiac Magnetic Resonance Imaging · NA · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

NCT07005037 — Swallowing Impairments in ICU Survivors and Community-Dwelling Adults · not yet recruiting
NCT07527273 — Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · NA · not yet recruiting
NCT07295288 — Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis · Phase 4 · not yet recruiting
NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03394859 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 28 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03394859.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing