Preventive Arterial Wall Phenotype in Subjects at Moderate Cardiovascular Risk Induced by Very Low-dose Fluvastatin/Valsartan Combination: a Pilot Study (AGE-ZT)

NCT03393377 NA COMPLETED

The study was designed to test whether short-term treatment with a very low-dose combination of fluvastatin and valsartan could induce improvement of endothelial function, arterial stiffness, vascular inflammation, oxidative stress and expression of protective genes in subjects with moderate cardiovascular risk.

Details

Lead sponsor	University Medical Centre Ljubljana
Phase	NA
Status	COMPLETED
Enrolment	20
Start date	2014-09
Completion	2017-06

Conditions

• Atherosclerosis

Interventions

• fluvastatin 10 mg and valsartan 20 mg
• placebo

Primary outcomes

• brachial flow-mediated dilatation (FMD) — 30 days
  FMD measured by ultrasound on right brachial artery (as result of reactive hyperaemia)
• reactive hyperaemia index (RHI) — 30 days
  RHI measured by Endopat device
• beta stiffness coefficient — 30 days
  assessed by ultrasound employing e-Tracking on right common carotid artery
• carotid pulse wave velocity (c-PWV) — 30 days
  assessed by ultrasound employing e-Tracking on right common carotid artery
• carotid-femoral PWV (cf-PWV) — 30 days
  cf-PWV measured by Sphygmocor device
• high-sensitivity C-reactive protein (hs-CRP) — 30 days
  inflammatory marker