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NCT03391362
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases
NA trial testing Stereotactic Radiation in Brain Metastases in 100 participants. Participants enrolled and being followed up; not accepting new ones.
1 February 2025
Quick facts
| Lead sponsor | Dana-Farber Cancer Institute |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 23 February 2018 |
| Primary completion | 1 February 2025 |
| Estimated completion | 1 February 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Stereotactic Radiation
Conditions studied
- Brain Metastases — all drugs for Brain Metastases →
- Small Cell Lung Cancer — all drugs for Small Cell Lung Cancer →
Sponsor
Dana-Farber Cancer Institute
Who can join
18 and older, any sex, with Brain Metastases or Small Cell Lung Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research study is studying stereotactic radiation (focused/pinpoint radiation that targets each individual tumor but not the surrounding brain) instead of whole-brain radiation (radiation targeting the entire brain) as a possible treatment for patients with small cell lung cancer and 1-10 brain metastases. The intervention involved in this study is: -Stereotactic (focused, pinpoint) radiation
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Epidemiology of brain metastases and leptomeningeal disease.
Lamba N, Wen PY, Aizer AA. · · 2021 · cited 264× · PMID 33908612 · DOI 10.1093/neuonc/noab101 -
Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions.
Aizer AA, Lamba N, Ahluwalia MS, Aldape K, et al · · 2022 · cited 116× · PMID 35762249 · DOI 10.1093/neuonc/noac118 -
Current Management and Progress in Radiotherapy for Small Cell Lung Cancer.
Tjong MC, Mak DY, Shahi J, Li GJ, et al · · 2020 · cited 23× · PMID 32760673 · DOI 10.3389/fonc.2020.01146 -
Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial.
Aizer AA, Tanguturi SK, Shi DD, Catalano PJ, et al · · 2025 · cited 11× · PMID 40644657 · DOI 10.1200/jco-25-00056 -
Modern Stereotactic Radiotherapy for Brain Metastases from Lung Cancer: Current Trends and Future Perspectives Based on Integrated Translational Approaches.
Levis M, Gastino A, De Giorgi G, Mantovani C, et al · · 2023 · cited 11× · PMID 37760591 · DOI 10.3390/cancers15184622 -
A multidisciplinary management algorithm for brain metastases.
Ramos A, Giantini-Larsen A, Pannullo SC, Brandmaier A, et al · · 2022 · cited 11× · PMID 36532509 · DOI 10.1093/noajnl/vdac176 -
Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects.
Uto M, Torizuka D, Mizowaki T. · · 2022 · cited 10× · PMID 36057071 · DOI 10.1007/s11604-022-01333-7 -
GOECP/SEOR radiotherapy guidelines for small-cell lung cancer.
Couñago F, de la Pinta C, Gonzalo S, Fernández C, et al · · 2021 · cited 8× · PMID 33767969 · DOI 10.5306/wjco.v12.i3.115
Verify or expand the search:
- PubMed search for NCT03391362
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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- NCT07227610 — Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT) · Phase 2 · recruiting
- NCT07448493 — Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer · active not recruiting
- NCT07053033 — Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR Be · Phase 2 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03391362 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dana-Farber Cancer Institute
- Last refreshed: 23 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03391362.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing