NCT03390517 (FLAG) is a NA clinical trial of Fluorescence angiography with indocianyne green in Rectal Cancer, sponsored by State Scientific Centre of Coloproctology, Russian Federation.

Who is sponsoring NCT03390517?

NCT03390517 is sponsored by State Scientific Centre of Coloproctology, Russian Federation.

What drugs are being tested in NCT03390517?

Interventions in NCT03390517: Fluorescence angiography with indocianyne green.

What condition does NCT03390517 study?

NCT03390517 studies Rectal Cancer, Sigmoid Cancer.

Is NCT03390517 still recruiting?

NCT03390517 is currently completed. Last updated 25 September 2019.

Last reviewed 2019-09-25 · How we verify

NCT03390517: FLAG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial)

Completed NA Last updated 25 September 2019

What this trial tests

NA trial testing Fluorescence angiography with indocianyne green in Rectal Cancer in 377 participants. Completed in 22 September 2019.

Timeline

9 November 2017

Primary endpoint
22 August 2019

22 September 2019

Quick facts

Lead sponsor	State Scientific Centre of Coloproctology, Russian Federation
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	377
Start date	9 November 2017
Primary completion	22 August 2019
Estimated completion	22 September 2019
Sites	1 location across Russia

Drugs / interventions tested

Fluorescence angiography with indocianyne green

Conditions studied

Rectal Cancer — all drugs for Rectal Cancer →
Sigmoid Cancer — all drugs for Sigmoid Cancer →

Sponsor

State Scientific Centre of Coloproctology, Russian Federation — full company profile →

Who can join

18 and older, any sex, with Rectal Cancer or Sigmoid Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized, controlled, parallel study to determine the difference in post-operative anastomotic leak rate of colorectal anastomosis where colon and rectal tissue perfusion is evaluated using fluorescence angiography with indocyanine green and without this method.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The problem of colorectal anastomosis safety.
Kryzauskas M, Poskus E, Dulskas A, Bausys A, et al · · 2020 · cited 13× · PMID 31914032 · DOI 10.1097/md.0000000000018560
Role of near-infrared fluorescence in colorectal surgery.
Zocola E, Meyer J, Christou N, Liot E, et al · · 2021 · cited 10× · PMID 34497444 · DOI 10.3748/wjg.v27.i31.5189

Verify or expand the search:

Other recruiting trials for Rectal Cancer

Currently open trials in the same condition.

NCT07528209 — Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer · Phase 3 · recruiting
NCT07537998 — Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a · Phase 2, PHASE3 · recruiting
NCT07501845 — Registry Maastro Applicator · recruiting
NCT07369531 — The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-pres · NA · recruiting
NCT07505472 — Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Wit · Phase 2, PHASE3 · recruiting

Other State Scientific Centre of Coloproctology, Russian Federation trials

Trials by the same sponsor.

NCT07268261 — Combined Method of Surgical Treatment of Anal Fissure · NA · recruiting
NCT05598164 — Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure · NA · unknown
NCT05495776 — Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorectal Cancer · recruiting
NCT05117697 — Surgical Treatment of a Chronic Anal Fissure · NA · unknown
NCT05228054 — Treatment of Hemorrhoid With 1940nm Laser Procedure · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03390517 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by State Scientific Centre of Coloproctology, Russian Federation
Last refreshed: 25 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03390517.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing