Last reviewed · How we verify
NCT03386227: PAPET
Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
NA trial testing Withholding antibiotic prophylaxis in Assisted Reproductive Technology in 96 participants. Terminated before completion.
30 June 2019
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 96 |
| Start date | 21 January 2018 |
| Primary completion | 30 June 2019 |
| Estimated completion | 31 July 2019 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Withholding antibiotic prophylaxis
Conditions studied
- Assisted Reproductive Technology — all drugs for Assisted Reproductive Technology →
- Antibiotic Prophylaxis — all drugs for Antibiotic Prophylaxis →
- Embryo Transfer — all drugs for Embryo Transfer →
Sponsor
Washington University School of Medicine
Who can join
Adults 18 to 43, any sex, with Assisted Reproductive Technology or Antibiotic Prophylaxis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this study is to determine the impact on clinical pregnancy rate of withholding routine prophylactic antibiotic therapy during IVF. The hypothesis is that withholding antibiotic prophylaxis will be non-inferior to routine administration. To test this hypothesis, the investigators will conduct a randomized controlled non inferiority trial. Additionally an exploratory study will be conducted among the first 30 patients undergoing their first cycle enrolled to evaluate the microbiome across the IVF cycle, in addition to the human virome
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association of vaginal bacterial communities and reproductive outcomes with prophylactic antibiotic exposure in a subfertile population undergoing in vitro fertilization: a prospective exploratory study.
Eskew AM, Stout MJ, Bedrick BS, Riley JK, et al · · 2021 · cited 11× · PMID 34632426 · DOI 10.1016/j.xfss.2021.01.002
Verify or expand the search:
- PubMed search for NCT03386227
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Assisted Reproductive Technology
Currently open trials in the same condition.
- NCT06770972 — Family Foundations for Individuals Pregnant Via ART · NA · recruiting
- NCT07384676 — Environmental and Behavioral Factors in Infertility and ART Outcomes · recruiting
- NCT06599528 — A Comparing Study Between SJ04 and Ovidrel® in Healthy Subjects · Phase 1 · recruiting
- NCT07532629 — Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes · recruiting
- NCT07257250 — Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation · recruiting
Other Washington University School of Medicine trials
Trials by the same sponsor.
- NCT05521997 — Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer · Phase 2 · not yet recruiting
- NCT07101666 — Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer · Phase 2 · not yet recruiting
- NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
- NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
- NCT07419464 — 5-Fluorouracil Response and Optimization STudy (The FROST Trial) · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03386227 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 18 August 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03386227.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing