NCT03382158 is a clinical trial in Pleuropulmonary Blastoma, sponsored by Children's Hospitals and Clinics of Minnesota.

Who is sponsoring NCT03382158?

NCT03382158 is sponsored by Children's Hospitals and Clinics of Minnesota.

What condition does NCT03382158 study?

NCT03382158 studies Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma, Wilms Tumor, Pineoblastoma, Renal Sarcoma, Nodular Hyperplasia of Thyroid, Nasal Chondromesenchymal Hamartoma, Ciliary Body Medulloepithelioma, Neuroblastoma, Pituitary Cancer, Embryonal Rhabdomyosarcoma, Ovarian Sarcoma, Gynandroblastoma, Thyroid Carcinoma, Embryonal Rhabdomyosarcoma of Vagina (Diagnosis), Embryonal Rhabdomyosarcoma of Uterus (Diagnosis), Embryonal Rhabdomyosarcoma of Cervix.

Is NCT03382158 still recruiting?

NCT03382158 is currently recruiting now. Last updated 30 January 2025.

Last reviewed 2025-01-30 · How we verify

NCT03382158

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

International PPB/DICER1 Registry

Recruiting now Last updated 30 January 2025

What this trial tests

trial in Pleuropulmonary Blastoma in 3,400 participants. Currently enrolling.

Timeline

6 December 2016

Primary endpoint
6 December 2030

6 December 2035

Quick facts

Lead sponsor	Children's Hospitals and Clinics of Minnesota
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	3,400
Start date	6 December 2016
Primary completion	6 December 2030
Estimated completion	6 December 2035
Sites	1 location across United States

Conditions studied

Pleuropulmonary Blastoma — all drugs for Pleuropulmonary Blastoma →
Sertoli-Leydig Cell Tumor — all drugs for Sertoli-Leydig Cell Tumor →
DICER1 Syndrome — all drugs for DICER1 Syndrome →
Cystic Nephroma — all drugs for Cystic Nephroma →

Sponsor

Children's Hospitals and Clinics of Minnesota

Who can join

Adults 0 Minutes to 100, any sex, with Pleuropulmonary Blastoma or Sertoli-Leydig Cell Tumor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the treating institution. This study builds off of the 2009 study and will also seek to enroll individuals with DICER1-associated conditions, some of whom may present only with the DICER1 gene mutation, which will help the Registry understand how these tumors and conditions develop, their clinical course and the most effective treatments.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry.
Schultz KAP, Harris AK, Nelson AT, Watson D, et al · · 2023 · cited 23× · PMID 36137255 · DOI 10.1200/jco.21.02925
DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Nelson AT, Mallinger PHR, Harris AK, et al · · 2024 · cited 15× · PMID 39400264 · DOI 10.1158/1078-0432.ccr-24-1532
Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation.
Hatton JN, Frone MN, Cox HC, Crowley SB, et al · · 2023 · cited 14× · PMID 38084291 · DOI 10.1155/2023/9537832
Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.
Nelson AT, Harris AK, Watson D, Kamihara J, et al · · 2024 · cited 12× · PMID 38657450 · DOI 10.1016/j.ygyno.2024.04.005
Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry.
Schoettler PJ, Smith CC, Nishitani M, Harris AK, et al · · 2024 · cited 11× · PMID 38807260 · DOI 10.1002/pbc.31090
Prevalence of lung cysts in adolescents and adults with a germline DICER1 pathogenic/likely pathogenic variant: a report from the National Institutes of Health and International Pleuropulmonary Blastoma/DICER1 Registry.
Nelson AT, Vasta LM, Watson D, Kim J, et al · · 2024 · cited 11× · PMID 38508719 · DOI 10.1136/thorax-2023-221024
Landscape of germline cancer predisposition mutations testing and management in pediatrics: Implications for research and clinical care.
Shahani SA, Marcotte EL. · · 2022 · cited 11× · PMID 36225340 · DOI 10.3389/fped.2022.1011873
Nasal chondromesenchymal hamartomas in a cohort with pathogenic germline variation in DICER1.
Vasta LM, Nichols A, Harney LA, Best AF, et al · · 2020 · cited 9× · PMID 34164613 · DOI 10.4193/rhinol/20.007

Verify or expand the search:

Other recruiting trials for Pleuropulmonary Blastoma

Currently open trials in the same condition.

NCT06647953 — Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an An · Phase 3 · recruiting
NCT07072143 — An International Study on Pediatric Patients With Rare Tumors. · recruiting
NCT01247597 — DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study · recruiting

Other Children's Hospitals and Clinics of Minnesota trials

Trials by the same sponsor.

NCT07482982 — Firearm Screening in the Pediatric Emergency Department · NA · completed
NCT05283434 — Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries · Phase 2, PHASE3 · unknown
NCT04575649 — Neurodevelopmental Outcomes and Growth in Infants With Congenital Gastrointestinal Anomalies Requiring Neonatal Surgery · unknown
NCT03360643 — Point-of-Care Ultrasonography for Intussusception · NA · completed
NCT03522233 — Pediatric Appendicitis Risk Calculator (pARC) in Children With Appendix Ultrasounds · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03382158 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Children's Hospitals and Clinics of Minnesota
Last refreshed: 30 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03382158.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing