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NCT03381872: RENOVATE
Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease
NA trial testing Percutaneous coronary intervention for complex lesion in Coronary Artery Disease in 1,639 participants. Participants enrolled and being followed up; not accepting new ones.
10 May 2022
Quick facts
| Lead sponsor | Samsung Medical Center |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 1,639 |
| Start date | 10 May 2018 |
| Primary completion | 10 May 2022 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Percutaneous coronary intervention for complex lesion
- Drug-eluting stent
- Intravascular imaging (IVUS or OCT)
- Drug-coated balloon
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Atherosclerosis — all drugs for Atherosclerosis →
Sponsor
Samsung Medical Center
Who can join
19 and older, any sex, with Coronary Artery Disease or Atherosclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to compare clinical outcomes between intravascular imaging-guided versus angiography-guided percutaneous coronary intervention (PCI) in complex lesions.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Intravascular Imaging-Guided or Angiography-Guided Complex PCI.
Lee JM, Choi KH, Song YB, Lee JY, et al · · 2023 · cited 361× · PMID 36876735 · DOI 10.1056/nejmoa2216607 -
Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial.
Hong D, Lee J, Lee H, Cho J, et al · · 2024 · cited 17× · PMID 38477162 · DOI 10.1161/circoutcomes.123.010230 -
Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention.
Kwon W, Lee JM, Yun KH, Choi KH, et al · · 2023 · cited 16× · PMID 38018841 · DOI 10.1161/circinterventions.123.013359 -
Impact of Intravascular Imaging-Guided Stent Optimization According to Clinical Presentation in Patients Undergoing Complex PCI.
Lee SY, Choi KH, Kim CJ, Lee JM, et al · · 2024 · cited 7× · PMID 38811104 · DOI 10.1016/j.jcin.2024.03.021 -
Intravascular Imaging-Guided Percutaneous Coronary Intervention Before and After Standardized Optimization Protocols.
Kwon W, Hong D, Choi KH, Lee SH, et al · · 2024 · cited 7× · PMID 38267144 · DOI 10.1016/j.jcin.2023.10.062 -
Intravascular Imaging in Patients With Complex Coronary Lesions and Chronic Kidney Disease.
Kwon W, Choi KH, Song YB, Park YH, et al · · 2023 · cited 7× · PMID 38019512 · DOI 10.1001/jamanetworkopen.2023.45554 -
Intracoronary Imaging: Current Practice and Future Perspectives.
Tsigkas G, Spyropoulou P, Bousoula E, Apostolos A, et al · · 2023 · cited 6× · PMID 39077408 · DOI 10.31083/j.rcm2402039 -
Intravascular Imaging Predictors Associated With Cardiovascular Events After Complex PCIs.
Lee JM, Lee SY, Kwon W, Lee SJ, et al · · 2025 · cited 4× · PMID 39965046 · DOI 10.1161/circinterventions.124.014920
Verify or expand the search:
- PubMed search for NCT03381872
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Samsung Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03381872 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Samsung Medical Center
- Last refreshed: 22 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03381872.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing