NCT03380858 (ANASTOSEAL) is a clinical trial of colectomy in Colorectal Cancer, sponsored by National Cancer Institute, Naples.

Who is sponsoring NCT03380858?

NCT03380858 is sponsored by National Cancer Institute, Naples.

What drugs are being tested in NCT03380858?

Interventions in NCT03380858: colectomy.

What condition does NCT03380858 study?

NCT03380858 studies Colorectal Cancer.

Is NCT03380858 still recruiting?

NCT03380858 is currently status unknown. Last updated 16 January 2018.

Last reviewed 2018-01-16 · How we verify

NCT03380858: ANASTOSEAL

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

REINFORCEMENT ANASTOMOSIS WITH Modified Cyanacrylate IN Patients Undergoing to Oncologic Colorectal Surgery With Colorectal Anastomosis

Status unknown Last updated 16 January 2018

What this trial tests

trial testing colectomy in Colorectal Cancer in 390 participants. Status unknown.

Timeline

2 November 2017

Primary endpoint
2 December 2017

2 May 2019

Quick facts

Lead sponsor	National Cancer Institute, Naples
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	390
Start date	2 November 2017
Primary completion	2 December 2017
Estimated completion	2 May 2019
Sites	1 location across Italy

Drugs / interventions tested

colectomy

Conditions studied

Colorectal Cancer — all drugs for Colorectal Cancer →

Sponsor

National Cancer Institute, Naples

Who can join

18 and older, any sex, with Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%. Preventing the anastomotic leak can therefore bring benefits to the patient and the health system. To date we have technologically advanced suturizers and the correct realization (well-vascularized margins, not in tension, etc.) remains crucial to prevent anastomotic dehiscence. Experimental results demonstrate that modified cyanacrylate is a suitable potential "reinforcement" on intestinal anastomoses (manual or linear intra-corporeal). Applied after mechanical anastomosis, it polymerizes in a short time, closing the spaces of the suture line between one point and the other, expressing an adhesive, hemostatic and sealing action on the tissues, also creating an effective antiseptic barrier towards of the most common infectious or pathogenic agents.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Improved outcomes with cyanoacrylate glue for ileocolic anastomosis in right colectomy: a multicenter study.
Rega D, Giulio E, Luca R, Muratore A, et al · · 2025 · cited 2× · PMID 40461001 · DOI 10.3393/ac.2024.00899.0128

Verify or expand the search:

Other recruiting trials for Colorectal Cancer

Currently open trials in the same condition.

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Other National Cancer Institute, Naples trials

Trials by the same sponsor.

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NCT06714357 — ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal Cancer · Phase 2 · recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03380858 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Cancer Institute, Naples
Last refreshed: 16 January 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03380858.

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