NCT03378973 is a Phase 4 clinical trial of Dexmedetomidine in Spinal Fusion, sponsored by Hospital for Special Surgery, New York.

Who is sponsoring NCT03378973?

NCT03378973 is sponsored by Hospital for Special Surgery, New York.

What drugs are being tested in NCT03378973?

Interventions in NCT03378973: Dexmedetomidine.

What condition does NCT03378973 study?

NCT03378973 studies Spinal Fusion.

Is NCT03378973 still recruiting?

NCT03378973 is currently terminated. Last updated 28 April 2020.

Are results published for NCT03378973?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-04-28 · How we verify

NCT03378973

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effects of Dexmedetomidine Dose on Motor Evoked Potentials

Terminated Phase 4 Results posted Last updated 28 April 2020

What this trial tests

Phase 4 trial testing Dexmedetomidine in Spinal Fusion in 7 participants. Terminated before completion.

Timeline

28 November 2018

Primary endpoint
17 October 2019

17 October 2019

Quick facts

Lead sponsor	Hospital for Special Surgery, New York
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	7
Start date	28 November 2018
Primary completion	17 October 2019
Estimated completion	17 October 2019
Sites	1 location across United States

Drugs / interventions tested

Dexmedetomidine (dexmedetomidine) — full drug profile →

Conditions studied

Spinal Fusion — all drugs for Spinal Fusion →

Sponsor

Hospital for Special Surgery, New York

Who can join

Adults 18 to 80, any sex, with Spinal Fusion. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Percent of Patients With Monitorable of Motor Evoked Potentials Primary · During a single surgery for the duration of the operation

Monitorable is defined as stable signals being present in 3 muscles in each lower extremity, with mean peak-to-peak amplitude of at least 50 uV, and with mean-normalized interquartile variability of 0.9 or less.

Group	Value	95% CI
Low Dose Dexmedetomidine	4
High Dose Dexmedetomidine	3

Sponsor's own description

This a parallel group, two-arm, randomized superiority trial that will compare the effect of two different doses of dexmedetomidine on motor evoked potentials during spine surgery

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Dexmedetomidine

Trials testing the same drug.

NCT06824077 — Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle · EARLY_PHASE1 · not yet recruiting
NCT07398066 — DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) · NA · not yet recruiting
NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
NCT07306702 — Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients · Phase 4 · withdrawn
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting

Other recruiting trials for Spinal Fusion

Currently open trials in the same condition.

NCT07217873 — IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study · Phase 2, PHASE3 · recruiting
NCT06471348 — Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine · NA · recruiting
NCT06368245 — Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions · recruiting
NCT06603831 — Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology · NA · recruiting
NCT06020417 — Pedicle Screw Malposition in Spine Arthrodesis Surgeries With O-ARM-guided Navigation · NA · recruiting

Other Hospital for Special Surgery, New York trials

Trials by the same sponsor.

NCT07226700 — Suzetrigine in Total Hip Arthroplasty · Phase 3 · recruiting
NCT06567873 — Gastric Ultrasound Assessment for Patients Taking Cannabis · completed
NCT07217964 — Natural Matrix Protein · enrolling by invitation
NCT06798493 — CSS-SR Validation Study · enrolling by invitation
NCT06180486 — Mindfulness Meditation Intervention Study · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03378973 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital for Special Surgery, New York
Last refreshed: 28 April 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03378973.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing