NCT03377504

Clinical Evaluation of the Effects of Mirror Therapy in Patients With Complex Regional Pain Syndrome (CRPS) Type 1

Completed NA Last updated 25 February 2020

What this trial tests

NA trial testing mirror therapy in Complex Regional Pain Syndrome Type I in 36 participants. Completed in 31 January 2020.

Timeline

1 March 2017

Primary endpoint
1 December 2019

31 January 2020

Quick facts

Lead sponsor	Ankara University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	36
Start date	1 March 2017
Primary completion	1 December 2019
Estimated completion	31 January 2020
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• mirror therapy
• Routine physical therapy and exercise program

Conditions studied

• Complex Regional Pain Syndrome Type I — all drugs for Complex Regional Pain Syndrome Type I →

Sponsor

Ankara University

Who can join

Adults 18 to 80, any sex, with Complex Regional Pain Syndrome Type I. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

CRPS Type 1 can occur after traumas, surgical applications or central nervous system disorders. The triggering factor in CRPS type 1 is fracture in about half of the cases. Mirror therapy is an innovative treatment approach that is cheap, easy to administer and non-invasive. It is thought that this treatment may be complementary to other rehabilitation methods.Neurophysiologic effects of mirror therapy are noted in the brain, especially in the parietal region, cerebellum, basal ganglia and premotor cortex. Mirror therapy is also effective through the mirror neuron system. Mirror therapy triggers neuroplasticity by increasing the connection between neurons in the brain and thereby enhances communication between the motor and the sensory cortex. Recent studies have shown the positive effects of mirror therapy in patients with CRPS Type 1 disease. There are two randomized controlled trials showing the efficacy of mirror therapy in patients with CRPS Type 1 after stroke. Only one pilot study was performed in patients with CRPS Type 1 who were traumatic origin. There are no randomized controlled trials investigating the efficacy of mirror therapy in CRPS Type 1 patients who developed secondary to trauma in the literature. The purpose of this study is to investigate the clinical effects of mirror therapy applied in addition to routine rehabilitation program in patients with traumatic CRPS Type 1. The investigators hypothesized that adjunctive mirror therapy to classical rehabilitation program would result in better outcomes compared with the classical program only.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.
   Smart KM, Ferraro MC, Wand BM, O'Connell NE. · · 2022 · cited 30× · PMID 35579382 · DOI 10.1002/14651858.cd010853.pub3
2. Effects of mirror therapy in post-traumatic complex regional pain syndrome type-1: a randomized controlled study.
   Özdemir EC, Elhan AH, Küçükdeveci AA. · · 2024 · cited 2× · PMID 39318174 · DOI 10.2340/jrm.v56.40417