Last reviewed · How we verify
NCT03376646
A Safety and Efficacy Study of Dissolve™ in Treatment of Coronary Small Vessel Disease
NA trial testing Cohort A: Dissolve™ in Coronary Small Vessel Disease in 277 participants. Completed in 15 April 2024.
10 January 2020
Quick facts
| Lead sponsor | DK Medical Technology (Suzhou) Co., Ltd. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 277 |
| Start date | 20 June 2018 |
| Primary completion | 10 January 2020 |
| Estimated completion | 15 April 2024 |
| Sites | 15 locations across China |
Drugs / interventions tested
- Cohort A: Dissolve™
- Cohort A: Resolute™ Integrity
- Cohort B: Dissolve™-2.00mm
Conditions studied
- Coronary Small Vessel Disease — all drugs for Coronary Small Vessel Disease →
Sponsor
DK Medical Technology (Suzhou) Co., Ltd.
Who can join
18 and older, any sex, with Coronary Small Vessel Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to evaluate the efficacy and safety in the treatment of Coronary Small Vessel Disease by drug coated balloon (DCB) Dissolve™ versus drug eluting stent (DES) Resolute™ Integrity.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Comparison of Drug-Coated Balloon and Drug-Eluting Stent for the Treatment of Small Vessel Disease (from the Dissolve SVD Randomized Trial).
Liu S, Zhou Y, Shen Z, Chen H, et al · · 2024 · cited 10× · PMID 37995506 · DOI 10.1016/j.amjcard.2023.05.057 -
Drug Coated Balloons Versus Drug-Eluting Stents in Patients With De Novo Coronary Artery Disease.
O'Callaghan D, Rai H, Giacoppo D, Coughlan JJ, et al · · 2025 · cited 5× · PMID 40662340 · DOI 10.1002/ccd.70005
Verify or expand the search:
- PubMed search for NCT03376646
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other DK Medical Technology (Suzhou) Co., Ltd. trials
Trials by the same sponsor.
- NCT05608655 — DKutting Balloon Versus Chocolate Balloon to Treat Femoral and Popliteal Artery Stenosis · NA · completed
- NCT05250193 — DK Score Coronary Scoring Balloon: a RCT Trial to Evaluate Acute Lumen Gain (SCORE CHINA) · NA · completed
- NCT04226599 — A Safety and Efficacy Study of Hemodialysis Arteriovenous Fistulae Stenosis Treated With DissolveAV · NA · completed
- NCT03373695 — A Safety and Efficacy Study of Dissolve™ in Treatment of Coronary In-stent Restenosis · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03376646 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by DK Medical Technology (Suzhou) Co., Ltd.
- Last refreshed: 20 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03376646.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing