NCT03375853: CC

Computerized Response Training Obesity Treatment

Completed NA Last updated 26 September 2023

What this trial tests

NA trial testing Computer Based Response Training Weight Loss Intervention in Obesity in 179 participants. Completed in 15 September 2023.

Timeline

15 July 2017

Primary endpoint
31 August 2023

15 September 2023

Quick facts

Lead sponsor	Oregon Research Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	179
Start date	15 July 2017
Primary completion	31 August 2023
Estimated completion	15 September 2023
Sites	1 location across United States

Drugs / interventions tested

• Computer Based Response Training Weight Loss Intervention
• Generic Response Training Control Intervention

Conditions studied

• Obesity — all drugs for Obesity →
• Hyperphagia — all drugs for Hyperphagia →
• Feeding and Eating Disorders — all drugs for Feeding and Eating Disorders →

Sponsor

Oregon Research Institute

Who can join

Adults 18 to 38, any sex, with Obesity or Hyperphagia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project will test whether a food response training intervention produces lasting body fat loss, use objective brain imaging to examine the mechanism of effect of this treatment and investigate the generalizability of the training to non-training foods, and examine factors that should amplify intervention effects to provide a test of the intervention theory. This novel treatment represents a bottom-up implicit training intervention that does not rely on executive control, prolonged caloric deprivation, and expensive clinicians to deliver, like behavioral weight loss treatments that have not produced lasting weight loss. If this computer-based response training intervention produces sustained body fat loss in overweight individuals, it could be easily implemented very broadly at almost no expense, addressing a leading public health problem.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obesity.
   Metzendorf MI, Wieland LS, Richter B. · · 2024 · cited 28× · PMID 38375882 · DOI 10.1002/14651858.cd013591.pub2
2. Efficacy of a food response and attention training treatment for obesity: A randomized placebo controlled trial.
   Stice E, Yokum S, Gau J, Veling H, et al · · 2022 · cited 12× · PMID 36058135 · DOI 10.1016/j.brat.2022.104183
3. Test-retest reliability of functional MRI food receipt, anticipated receipt, and picture tasks.
   Yokum S, Bohon C, Berkman E, Stice E. · · 2021 · cited 7× · PMID 33851199 · DOI 10.1093/ajcn/nqab096
4. Relation of BOLD response to food-specific and generic motor response inhibition tasks to body fat gain in adults with overweight and obesity.
   Yokum S, Stice E. · · 2023 · cited 3× · PMID 37094746 · DOI 10.1016/j.physbeh.2023.114206