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NCT03371901
Blood Flow Restriction Training in Patients With Weight Bearing Restrictions After Knee Surgery
NA trial testing Physical therapy with BFR-LLST in Cartilage, Articular in 42 participants. Completed in 14 May 2019.
14 May 2019
Quick facts
| Lead sponsor | Health Centre Nørrebro, City of Copenhagen |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 42 |
| Start date | 12 December 2017 |
| Primary completion | 14 May 2019 |
| Estimated completion | 14 May 2019 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Physical therapy with BFR-LLST
Conditions studied
- Cartilage, Articular — all drugs for Cartilage, Articular →
- Tibial Meniscus Injuries — all drugs for Tibial Meniscus Injuries →
Sponsor
Health Centre Nørrebro, City of Copenhagen
Who can join
Adults 18 to 70, any sex, with Cartilage, Articular or Tibial Meniscus Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
After a cartilage or meniscus repair in the knee joint, the patients experience a pronounced and persistent decrease of knee-extension strength in the operated leg, which negatively affect patients' functional performance and quality of life. A possible novel exercise modality to increase muscle strength early is a moderate blood flow restriction with low-load strength training (BFR-LLST) exercise. BFR-LLST involves application of a wrapping device to restrict the blood flow to the muscle(s) during exercise. BFR- LLST requires much less load than traditional strength training and has shown to produce positive training adaptations such as muscle hypertrophy and strength in the lower extremity in healthy subjects and patients with a knee surgery. To our knowledge, early rehabilitation with BFR-LLST has never been investigated in a population with weight bearing restrictions, such as patients recovering from cartilage or meniscus repair in the knee joint. Fear of symptom exacerbation and adverse events have precluded BFR-LLST early after knee surgery. The purpose of this study is to examine the feasibility of 9 weeks of supervised rehabilitation with BFR-LLST early after cartilage or meniscus repair in the knee joint.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Blood flow restriction added to usual care exercise in patients with early weight bearing restrictions after cartilage or meniscus repair in the knee joint: a feasibility study.
Jakobsen TL, Thorborg K, Fisker J, Kallemose T, et al · · 2022 · cited 2× · PMID 36192606 · DOI 10.1186/s40634-022-00533-4
Verify or expand the search:
- PubMed search for NCT03371901
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Related trials
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03371901 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Health Centre Nørrebro, City of Copenhagen
- Last refreshed: 24 May 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03371901.
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