Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines in Children Under 2 Years Old in Argentina

NCT03368495 Phase 4 COMPLETED

This study evaluates seroconversion against measles, mumps, rubella and yellow fever following vaccination. One-third of children will receive both yellow fever and measles, mumps, and rubella (MMR) vaccines on the same day; one- third of children will receive MMR vaccine at enrollment followed by yellow fever vaccine 4 weeks later; one-third of children will receive yellow fever vaccine at enrollment followed by MMR vaccine 4 weeks later.

Details

Lead sponsor	Alba Maria Ropero
Phase	Phase 4
Status	COMPLETED
Enrolment	851
Start date	2015-11-23
Completion	2018-06-30

Conditions

• Vaccine Response Impaired

Interventions

• Co-administration of MMR/YF
• MMR followed by YF
• YF followed by MMR

Primary outcomes

• Seroconversion after yellow fever vaccination using the plaque reduction neutralization test (PRNT). — 28-35 days post-vaccination
  PRNTs will be used to measure antibody titers for yellow fever.
• Seroconversion after MMR vaccination using the ELISA method. — 28-35 days post-vaccination.
  The ELISA method will be used to measure antibody titers for measles, mumps, and rubella.

Countries

Argentina