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NCT03366181
SGLT2i As Anti Arrhythmic Therapy to Prevent Sudden Cardiac Deaths.
trial in Heart Failure in 500 participants. Completed in 26 November 2017.
20 November 2017
Quick facts
| Lead sponsor | University of Campania Luigi Vanvitelli |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 1 November 2017 |
| Primary completion | 20 November 2017 |
| Estimated completion | 26 November 2017 |
| Sites | 1 location across Italy |
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- ICD — all drugs for ICD →
- Diabetes Mellitus Type 2 — all drugs for Diabetes Mellitus Type 2 →
- SGLT2i — all drugs for SGLT2i →
Sponsor
University of Campania Luigi Vanvitelli
Who can join
Adults 18 to 75, any sex, with Heart Failure or ICD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Failing heart negative remodeling alterations might provide electrical heterogeneity and cardiac remodeling, thus potentially contributing to the occurrence of ventricular arrhythmia and subsequent sudden cardiac death (SCD). In this study we have prospectively investigated whether sodium glucose transporte-2 inhibitors (SGLT2i) could modulate serum markers of heart failure (ultra sensitive Troponin , B type Natriuretic Peptide (BNP), C reactive protein (CRP), the heart rate (HR) and serum catecholamines in patients with type 2 diabetes mellitus (T2DM), and be used as predictors for the occurrence of malignant ventricular arrhythmias (VTAs) in patients who had received an Implantable Cardioverter Defibrillator (ICD) for primary prevention. In these T2DM patients with ICD we investigated the functionality of devices, the appropriate and inappropriate shocks, and the hospitalizations for heart failure and the cardiac deaths.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03366181
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Other University of Campania Luigi Vanvitelli trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03366181 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Campania Luigi Vanvitelli
- Last refreshed: 20 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03366181.
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