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NCT03366038: SMMP
Shark Mouth Modified Pancreaticojejunostomy
trial testing Shark Mouth Modified Pancreaticojejunostomy in Pancreatic Cancer in 120 participants. Status unknown.
9 December 2019
Quick facts
| Lead sponsor | Peking University Third Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 8 December 2017 |
| Primary completion | 9 December 2019 |
| Estimated completion | 1 May 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- Shark Mouth Modified Pancreaticojejunostomy
Conditions studied
- Pancreatic Cancer — all drugs for Pancreatic Cancer →
- Periampullary Carcinoma — all drugs for Periampullary Carcinoma →
Sponsor
Peking University Third Hospital
Who can join
Adults 18 to 80, any sex, with Pancreatic Cancer or Periampullary Carcinoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pancreaticoduodenectomy (PD) is one of the most complicated surgical procedure and one of the standard treatments for benign and malignant disease of pancreatic head and periampullary region. Improvements in surgical techniques and the perioperative management of patients undergoing PD have reduced the surgical mortality rates to less than 3% in high-volume medical centers. However, the incidence of postoperative complication remains high, which ranges from 30% to 50% and the pancreatic fistula rate ranges from 5% to 40%. The key point of PD is still the enteric reconstruction of pancreatic stump. There were different techniques of enteric reconstruction, including: invagination pancreaticojejunostomy, binding pancreaticojejunostomy, duct-to-mucosa pancreaticojejunostomy, Roux-en-Y pancreaticojejunostomy, and pancreaticogastrostomy and each technique had its advantages and disadvantages. We established a new digestive reconstruction technique named shark mouth modified pancreaticojejunostomy, which had theoretical advantages including easier performed; lower tension and less complication. The shark mouth modified pancreaticojejunostomy is an end-to-end pancreaticojejunostomy procedure which is between invagination pancreaticojejunostomy and binding pancreaticojejunostomy.The remnant of jejunum is shaped as shark mouth and then sutured with the pancreas remnant. After the surgery, the patients will be well followed up. The pancreaticojejunostomy time, post-operation complication, mortality and hospital stay will be documented to study the safety, efficiency and advantage of this new procedure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Shark mouth pancreaticojejunostomy: a new enteric reconstruction procedure of pancreatic stump.
Wang HY, Li MX, Xiu DR. · · 2019 · cited 4× · PMID 30896569 · DOI 10.1097/cm9.0000000000000219
Verify or expand the search:
- PubMed search for NCT03366038
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03366038 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Peking University Third Hospital
- Last refreshed: 5 April 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03366038.
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