Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume

NCT03364465 NA COMPLETED

During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis. Nevertheless, it is not known if, during one-lung ventilation with constant low VT, moderate levels of PEEP combined with lung recruitment maneuvers are superior to variable low tidal volume for intraoperative oxygenation and protection against PPCs. Aim of the study is to compare a strategy using constant tidal volume with recruitment maneuvers versus variable tidal volume with recruitment maneuvers during thoracic surgery in adults. We hypothesize that in adult, non-obese patients undergoing thoracic surgery under standardized OLV with variable tidal volumes, modearte PEEP and recruitment maneuvers as compared to constant without recruitment maneuvers prevent PPCs. Patients will be randomly assigned to one of two groups: FIX TIDAL VOLUME GROUP (Groupfix): mechanical ventilation with constant (6 ml/kgIBW) tidal volume and PEEP of 5 cmH2O with recruitment maneuvers VARIABLE TIDAL VOLUME GROUP (Groupvar): mechanical ventilation with variable (6 ml/kgIBW ± 33%) tidal volume with variable respiratory rate to maintain constant minute ventilation and PEEP of 5 cmH2O with recruitment maneuvers.

Details

Lead sponsor	University of Debrecen
Phase	NA
Status	COMPLETED
Enrolment	140
Start date	Wed Feb 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Apr 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Hypoxemia
• Pulmonary Sepsis
• ARDS, Human
• Pneumonia

Interventions

• change of ventilatory settings

Countries

Hungary