NCT03363529: ROOM-LIGHT

ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards

Completed NA Last updated 25 February 2026

What this trial tests

NA trial testing Dynamic light in Depression in 15 participants. Completed in 19 March 2019.

Timeline

16 November 2017

Primary endpoint
19 December 2018

19 March 2019

Quick facts

Lead sponsor	University Hospital Bispebjerg and Frederiksberg
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	15
Start date	16 November 2017
Primary completion	19 December 2018
Estimated completion	19 March 2019
Sites	1 location across Denmark

Drugs / interventions tested

• Dynamic light
• Standard

Conditions studied

• Depression — all drugs for Depression →
• Light; Therapy, Complications — all drugs for Light; Therapy, Complications →
• Sleep Disorders, Circadian Rhythm — all drugs for Sleep Disorders, Circadian Rhythm →

Sponsor

University Hospital Bispebjerg and Frederiksberg

Who can join

18 and older, any sex, with Depression or Light; Therapy, Complications. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Depression is a major health challenge, and despite developments in pharmacotherapy and psychotherapy a substantial part of patients will only recover very slowly and incompletely, and 10-25 % of the patients are resistant to treatment. Therefore, new treatment initiatives are in demand. Chronotherapeutics can regulate diurnal rhythms and sleep, and have shown promising results on antidepressant effects. Among chronotherapeutic treatment modalities, Bright Light Therapy (BLT) has been used in treatment of depression and sleep disorders for several decades with both an antidepressant and a sleep improving effect. BLT has also been shown to augment antidepressant therapy.

Objectives. The objective of this trial is to investigate the feasibility of a combination of LED-light armatures aiming to mimic sunlight, when installed in the patient rooms of a psychiatric inpatient Ward. Investigators has opted for using a randomized design that will subsequently be tested in a larger clinical trial with depression severity as the primary outcome. In this feasibility study investigators will register the stability of the system, the influence of the light on patients regarding tolerability, comfort, depression level, and sleep. Investigators also so want to measure and collect specific light-data on the Non-image-forming light (NIF) by using specially designed light sensors to capture the spectral distribution of the light. Finally investigators will test the electronic case report form (eCRF) that has been designed for the trial.

Design. The design is a randomised controlled feasibility trial with two arms: an active dynamic light trial arm and a standard light trial arm with blinding of depression outcome assessors (Hamilton depression rating scale), data collection, and data analyses. Randomization will be with a rate for active and standard of 2 to 1.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Dynamic LED light versus static LED light for depressed inpatients: results from a randomized feasibility trial.
   Volf C, Aggestrup AS, Svendsen SD, Hansen TS, et al · · 2020 · cited 5× · PMID 31956421 · DOI 10.1186/s40814-019-0548-9