NCT03362775: MOTANA

EEG Analysis During Light Propofol Sedation

Status unknown Phase 1 Last updated 16 February 2023

What this trial tests

Phase 1 trial testing Propofol in Electroencephalography in 30 participants. Status unknown.

Timeline

1 November 2018

Primary endpoint
30 October 2023

31 December 2023

Quick facts

Lead sponsor	Central Hospital, Nancy, France
Phase	Phase 1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	30
Start date	1 November 2018
Primary completion	30 October 2023
Estimated completion	31 December 2023
Sites	1 location across France

Drugs / interventions tested

• Propofol (Propofol) — full drug profile →

Conditions studied

• Electroencephalography — all drugs for Electroencephalography →

Sponsor

Central Hospital, Nancy, France

Who can join

Adults 18 to 28, male only, with Electroencephalography. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal. EEG signals will be recorded during the realization of intentional movements and movement intentions by the healthy volunteers, as well as during median nerve stimulation before and during propofol perfusion according to a target control infusion. (0 µg/mL; 0.5 µg/mL and 1 µg/mL).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. MOTANA: study protocol to investigate motor cerebral activity during a propofol sedation.
   Rimbert S, Schmartz D, Bougrain L, Meistelman C, et al · · 2019 · cited 5× · PMID 31455386 · DOI 10.1186/s13063-019-3596-9