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NCT03361514
Discontinuation of Antidepressant Medication in Primary Care.
NA trial testing Supported Protocolized Discontinuation (SPD) in Antidepressants in 119 participants. Completed in 1 August 2019.
1 August 2019
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 119 |
| Start date | 20 February 2017 |
| Primary completion | 1 August 2019 |
| Estimated completion | 1 August 2019 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Supported Protocolized Discontinuation (SPD)
- Mindfulness Based Cognitive Therapy (MBCT)
Conditions studied
- Antidepressants — all drugs for Antidepressants →
Sponsor
Radboud University Medical Center
Who can join
18 and older, any sex, with Antidepressants. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To investigate the effectiveness of the combination of Supported Protocolized Discontinuation (SPD) and Mindfulness-Based Cognitive Therapy (MBCT) in comparison with SPD alone in successful discontinuation of long-term use of antidepressants in primary care.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Discontinuation of antidepressant medication in primary care supported by monitoring plus mindfulness-based cognitive therapy versus monitoring alone: design and protocol of a cluster randomized controlled trial.
Wentink C, Huijbers MJ, Lucassen P, Kramers C, et al · · 2019 · cited 9× · PMID 31349796 · DOI 10.1186/s12875-019-0989-5 -
Supporting antidepressant discontinuation using mindfulness plus monitoring versus monitoring alone: A cluster randomized trial in general practice.
Huijbers MJ, Wentink C, Lucassen PLBJ, Kramers C, et al · · 2023 · cited 3× · PMID 37669281 · DOI 10.1371/journal.pone.0290965
Verify or expand the search:
- PubMed search for NCT03361514
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Antidepressants
Currently open trials in the same condition.
- NCT05191277 — Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation · NA · active not recruiting
Other Radboud University Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03361514 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 5 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03361514.
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