NCT03361280 is a Phase 1, PHASE2 clinical trial of Beta blocker in Chronic Kidney Diseases, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's.

What drugs are being tested in NCT03361280?

Interventions in NCT03361280: Beta blocker.

What condition does NCT03361280 study?

NCT03361280 studies Chronic Kidney Diseases.

Is NCT03361280 still recruiting?

NCT03361280 is currently completed. Last updated 4 December 2017.

Last reviewed 2017-12-04 · How we verify

NCT03361280

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Removal of Beta Blocker Drugs by Hemodialysis

Completed Phase 1, PHASE2 Last updated 4 December 2017

What this trial tests

Phase 1, PHASE2 trial testing Beta blocker in Chronic Kidney Diseases in 8 participants. Completed in 10 March 2016.

Timeline

27 February 2015

Primary endpoint
10 March 2016

10 March 2016

Quick facts

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	8
Start date	27 February 2015
Primary completion	10 March 2016
Estimated completion	10 March 2016

Drugs / interventions tested

Beta blocker — full drug profile →

Conditions studied

Chronic Kidney Diseases — all drugs for Chronic Kidney Diseases →

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Who can join

18 and older, any sex, with Chronic Kidney Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

<i>β</i>-Blocker Dialyzability in Maintenance Hemodialysis Patients: A Randomized Clinical Trial.
Tieu A, Velenosi TJ, Kucey AS, Weir MA, et al · · 2018 · cited 35× · PMID 29519953 · DOI 10.2215/cjn.07470717

Verify or expand the search:

Other trials of Beta blocker

Trials testing the same drug.

NCT05721170 — Impact of Beta Blockers on TAVI (BETA-TAVI) · Phase 4 · recruiting
NCT05019027 — N-of-1 for Beta-Blockers in Cardiac Amyloidosis · Phase 4 · enrolling by invitation
NCT05786417 — LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions · Phase 4 · recruiting
NCT06371222 — Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm · Phase 4 · completed
NCT04575675 — Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy · Phase 4 · completed

Other recruiting trials for Chronic Kidney Diseases

Currently open trials in the same condition.

NCT06593392 — Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus · Phase 2 · recruiting
NCT07358572 — Eye-Brain-Kidney in CKD · recruiting
NCT06463483 — Automated Insulin Delivery in Adults With Advanced Kidney Disease · NA · recruiting
NCT06927024 — Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD) · NA · recruiting
NCT07115953 — Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension · NA · recruiting

Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials

Trials by the same sponsor.

NCT07588711 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury · NA · not yet recruiting
NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03361280 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Last refreshed: 4 December 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03361280.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing