NCT03360136

Open Clinical Trial of CBT-based Multiprofessional Rehabilitation for Exhaustion Disorder

Completed NA Last updated 21 February 2023

What this trial tests

NA trial testing Multi-professional CBT-rehabilitation in Exhaustion; Syndrome in 1,000 participants. Completed in 29 December 2020.

Timeline

1 October 2017

Primary endpoint
29 December 2020

29 December 2020

Quick facts

Lead sponsor	Uppsala University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	1,000
Start date	1 October 2017
Primary completion	29 December 2020
Estimated completion	29 December 2020
Sites	2 locations across Sweden

Drugs / interventions tested

• Multi-professional CBT-rehabilitation

Conditions studied

• Exhaustion; Syndrome — all drugs for Exhaustion; Syndrome →
• Burnout, Professional — all drugs for Burnout, Professional →
• Burnout Syndrome — all drugs for Burnout Syndrome →
• Adjustment Disorders — all drugs for Adjustment Disorders →

Sponsor

Uppsala University

Who can join

Adults 18 to 64, any sex, with Exhaustion; Syndrome or Burnout, Professional. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stress-related mental disorders are today the leading cause of long-term sick leave in Sweden, and a large part of this increase is due to Clinical burnout, in Sweden called "Exhaustion disorder" (ED). Even though clinical guidelines recommend multi-professional rehabilitation (MPR) for ED, few studies have evaluated the effects of these treatment programs in clinical practice. This large-scale open clinical trial investigates whether MPR for ED seems to alleviate symptoms of ED and if it results in return-to-work.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Standardized multimodal intervention for stress-induced exhaustion disorder: an open trial in a clinical setting.
   van de Leur JC, Buhrman M, Åhs F, Rozental A, et al · · 2020 · cited 23× · PMID 33153461 · DOI 10.1186/s12888-020-02907-3
2. Associations between improvements in psychological variables and subsequent sick leave among persons receiving a multimodal intervention for exhaustion disorder.
   van de Leur JC, Buhrman M, Wallby K, Karlström A, et al · · 2023 · cited 3× · PMID 37821913 · DOI 10.1186/s12889-023-16799-x
3. A network analysis of exhaustion disorder symptoms throughout treatment.
   Mårtensson G, Johansson F, Buhrman M, Åhs F, et al · · 2024 · PMID 38783205 · DOI 10.1186/s12888-024-05842-9
4. Associations Between Improvements in Psychological Variables and Subsequent Sick Leave Among Persons Receiving a Multimodal Intervention for Exhaustion Disorder
   de Leur JCv, Buhrman M, Wallby K, Karlström A, et al · · 2023 · DOI 10.21203/rs.3.rs-2985838/v1