NCT03357016: MATISSE

HIIT Versus MICT on Abdominal Fat Mass and Lipid Oxidation in Postmenopausal Women (MATISSE)

Completed NA Last updated 10 August 2018

What this trial tests

NA trial testing Training programs in Overweight in 36 participants. Completed in 8 June 2018.

Timeline

1 February 2017

Primary endpoint
8 June 2018

8 June 2018

Quick facts

Lead sponsor	Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	36
Start date	1 February 2017
Primary completion	8 June 2018
Estimated completion	8 June 2018
Sites	1 location across France

Drugs / interventions tested

• Training programs

Conditions studied

• Overweight — all drugs for Overweight →
• Post Menopausal Women — all drugs for Post Menopausal Women →

Sponsor

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

Who can join

Adults 55 to 82, female only, with Overweight or Post Menopausal Women. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Abdominal fat mass accumulation is associated with an increase of cardiovascular disease (CVD) risk.

Most exercise programs designed for weight loss have focused on about 30 min several times per week of moderate intensity continuous training (MICT). Disappointingly, such exercise programs have led to either none or low fat loss. Accumulating evidence suggests that high intensity interval training (HIIT) should be an effective exercise protocol for reducing body fat of overweight individuals, especially at the abdominal level.

Resistance Training (RT) is associated with increased muscle mass and strength gain in main muscles groups. Thus, RT seems to be an interesting strategy to fight against deconditioning and autonomy loss with age. Development of muscle mass enhances resting metabolism rate. Thus, RT could raise daily energy expenditure ie. substrates' oxidation including lipids.

The aim of our study was to compare the effects of a 12-week moderate intensity continuous training (MICT) program with high intensity interval training (HIIT) program combined or not with a resistance training (RT) program on total abdominal and visceral fat mass and substrate utilization in postmenopausal women.

It is hypothesized that HIIT compared to MICT program would result in significantly greater whole body and regional fat mass losses (abdominal and visceral) and would improve lipid oxidation at rest and during prolonged moderate exercise. It is also hypothesized that HIIT associated with RT could be the best strategy to reduce fat mass.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.