NCT03353597 (RESET-YOUTH) is a Phase 1, PHASE2 clinical trial of Plasma Transfusion in Aging, sponsored by Chandra Duggirala.

Who is sponsoring NCT03353597?

NCT03353597 is sponsored by Chandra Duggirala.

What drugs are being tested in NCT03353597?

Interventions in NCT03353597: Plasma Transfusion.

Is NCT03353597 still recruiting?

NCT03353597 is currently status unknown. Last updated 17 January 2018.

Last reviewed 2018-01-17 · How we verify

NCT03353597: RESET-YOUTH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects

Status unknown Phase 1, PHASE2 Last updated 17 January 2018

What this trial tests

Phase 1, PHASE2 trial testing Plasma Transfusion in Aging in 2,120 participants. Status unknown.

Timeline

15 May 2018

Primary endpoint
15 June 2020

15 December 2022

Quick facts

Lead sponsor	Chandra Duggirala
Phase	Phase 1, PHASE2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	2,120
Start date	15 May 2018
Primary completion	15 June 2020
Estimated completion	15 December 2022
Sites	1 location across United States

Drugs / interventions tested

Plasma Transfusion — full drug profile →

Conditions studied

Aging — all drugs for Aging →

Sponsor

Chandra Duggirala

Who can join

40 and older, any sex, with Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial is designed to study the effects of monthly transfusions of young healthy male donor plasma on biological age as assessed by DNA methylation levels, and changes in cognitive, renal, and pulmonary function, muscle strength, telomere length, testosterone, estrogen, DHEAS, IGF-1, high resolution C-Reactive protein, and expression of P16INK4a in peripheral blood T lymphocytes and skin biopsies.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Targeting senescent cells in translational medicine.
Paez-Ribes M, González-Gualda E, Doherty GJ, Muñoz-Espín D. · · 2019 · cited 230× · PMID 31746100 · DOI 10.15252/emmm.201810234
Senescence under appraisal: hopes and challenges revisited.
Davan-Wetton CSA, Pessolano E, Perretti M, Montero-Melendez T. · · 2021 · cited 41× · PMID 33439271 · DOI 10.1007/s00018-020-03746-x
Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies.
Khalil R, Diab-Assaf M, Lemaitre JM. · · 2023 · cited 32× · PMID 36980256 · DOI 10.3390/cells12060915
Unraveling Histone Loss in Aging and Senescence.
Dubey SK, Dubey R, Kleinman ME. · · 2024 · cited 15× · PMID 38391933 · DOI 10.3390/cells13040320
Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions.
Vitorakis N, Piperi C. · · 2023 · cited 12× · PMID 38139167 · DOI 10.3390/ijms242417339
Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange.
Fuentealba M, Kiprov D, Schneider K, Mu WC, et al · · 2025 · cited 10× · PMID 40424097 · DOI 10.1111/acel.70103

Verify or expand the search:

Other recruiting trials for Aging

Currently open trials in the same condition.

NCT02831335 — Technical Development of Multi-Parametric Renocerebral MRI · recruiting
NCT07099053 — Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging · recruiting
NCT07504068 — Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in · NA · recruiting
NCT07525453 — Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults · NA · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03353597 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chandra Duggirala
Last refreshed: 17 January 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03353597.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing