Last reviewed · How we verify
NCT03352271: IIHD
Individualized Incremental Hemodialysis Study
NA trial testing Individualized Incremental hemodialysis in Hemodialysis Complication in 122 participants. Completed in 1 December 2020.
1 September 2020
Quick facts
| Lead sponsor | Alexandria University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 122 |
| Start date | 1 June 2017 |
| Primary completion | 1 September 2020 |
| Estimated completion | 1 December 2020 |
| Sites | 2 locations across Egypt |
Drugs / interventions tested
- Individualized Incremental hemodialysis
- Conventional thrice weekly hemodialysis
Conditions studied
- Hemodialysis Complication — all drugs for Hemodialysis Complication →
- ESRD — all drugs for ESRD →
- Renal Failure — all drugs for Renal Failure →
Sponsor
Alexandria University
Who can join
18 and older, any sex, with Hemodialysis Complication or ESRD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Thrice weekly hemodialysis has been the standard of care all-over the world for end-stage renal disease (ESRD) requiring renal replacement therapy (RRT). Despite being in the era of precision medicine and individualized healthcare, this program doesn't take into account patients with residual kidney function (RKF) who don't require a thrice weekly hemodialysis frequency. Incremental hemodialysis (defined as twice weekly hemodialysis initiation in incident hemodialysis patients with residual kidney function) has been raised as an alternative to the conventional thrice weekly dialysis. Retrospective trials has proved safety of a twice weekly initiation with comparative efficacy to the thrice weekly program. Despite that, there is paucity of prospective observational and rarity of randomized controlled trials comparing both regimens. In this study, the investigators tend to provide a more individualized incremental hemodialysis approach to incident hemodialysis patients with residual urine volume and RKF. The investigators will compare the results to ESRD patients initiating a thrice weekly hemodialysis program.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Incremental versus standard dialysis for people with kidney failure
Sabanayagam D, Hegerty K, Au E, Beruni N, et al · · 2023
Verify or expand the search:
- PubMed search for NCT03352271
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Alexandria University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03352271 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alexandria University
- Last refreshed: 13 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03352271.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing