Who is sponsoring NCT03351452?

NCT03351452 is sponsored by University of Bern.

What drugs are being tested in NCT03351452?

Interventions in NCT03351452: real anodal transcranial direct current stimulation, real transcranial alternating current stimulation, sham transcranial electric current stimulation.

What condition does NCT03351452 study?

NCT03351452 studies Healthy, Mild Cognitive Impairment, Alzheimer Disease.

Is NCT03351452 still recruiting?

NCT03351452 is currently completed. Last updated 13 March 2020.

Last reviewed 2020-03-13 · How we verify

NCT03351452

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

tES Effects on Associative Memory Performance

Completed NA Last updated 13 March 2020

What this trial tests

NA trial testing real anodal transcranial direct current stimulation in Healthy in 28 participants. Completed in 24 February 2020.

Timeline

9 April 2018

Primary endpoint
30 September 2018

24 February 2020

Quick facts

Lead sponsor	University of Bern
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	28
Start date	9 April 2018
Primary completion	30 September 2018
Estimated completion	24 February 2020
Sites	1 location across Switzerland

Drugs / interventions tested

real anodal transcranial direct current stimulation
real transcranial alternating current stimulation
sham transcranial electric current stimulation

Conditions studied

Healthy — all drugs for Healthy →
Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
Alzheimer Disease — all drugs for Alzheimer Disease →

Sponsor

University of Bern

Who can join

Adults 60 to 85, any sex, with Healthy or Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or early Alzheimer's disease. Therefore, tES methods might be a useful intervention tool for patients suffering from memory impairment in early terms of the disease. The present study aims at establishing a connection between the stimulation-induced changes on associative memory performance and its underlying neurophysiological parameters. tES effects and their underlying mechanisms will be compared between healthy elderly controls and clinical study populations receiving either real or sham tES over the left ventrolateral prefrontal cortex during an associative memory task.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes.
Gholamali Nezhad F, Martin J, Tassone VK, Swiderski A, et al · · 2024 · cited 7× · PMID 39211537 · DOI 10.3389/fpsyt.2024.1419243
The Potential for Neuromodulation in the Treatment of Alzheimer's Disease: A Review of Clinical Trials.
Jones T, Shalom M, Chalamgari A, Gold J, et al · · 2025 · PMID 40599507 · DOI 10.7759/cureus.85156

Verify or expand the search:

Other trials of real anodal transcranial direct current stimulation

Trials testing the same drug.

NCT03959462 — Supporting Decisions With Transcranial Direct Current Stimulation in Healthy Young and Elderly Individuals · NA · completed

Other recruiting trials for Healthy

Currently open trials in the same condition.

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NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other University of Bern trials

Trials by the same sponsor.

NCT05940662 — Cost Effectiveness of Various Implant Placement Protocols in the Esthetic Zone · Phase 4 · suspended
NCT02919163 — Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 6 of 7) · NA · not yet recruiting
NCT02919189 — Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 5 of 7) · NA · not yet recruiting
NCT04817592 — Characterization of the Corneal Biomechanics of Patients Treated by Corneal Lenticule Extraction for Advanced Refractive · not yet recruiting
NCT06806150 — The INSPIRE Study: INvestigation of Swiss Physicians Inner-life, Resilience, and Emotions · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03351452 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Bern
Last refreshed: 13 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03351452.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing