Single Shot Versus Multiple Shot Antibiotic Prophylaxis in Primary Joint Arthroplasty of the Hip and Knee, Comparison of Different Prophylaxis Regimes on the Risk of Revision for Infection

NCT03348254 COMPLETED

A retrospective study will be performed to compare the incidence of revision procedures performed for the treatment of postoperative periprosthetic joint infection (PJI) between patients treated with a single preoperative antibiotic prophylaxis and patients treated with multiple shot antibiotic prophylaxis following primary arthroplasty of hip or knee. This study will be conducted in two phases. In phase 1 the investigators will evaluate which antibiotic prophylaxes (type of antibiotic and duration of prophylaxis) are regularly used in the Netherlands, by contacting all orthopaedic centres implanting total hip and total knee prostheses. In phase 2 the investigators will compare infection rate (defined as revision for infection as registered in the LROI database) between a single-shot and multiple shot antibiotic prophylaxis. Knee and hip primary arthroplasties will be considered separately.

Details

Lead sponsor	Onze Lieve Vrouwe Gasthuis
Status	COMPLETED
Enrolment	242179
Start date	2016-04
Completion	2019-03

Conditions

• Arthroplasty, Replacement, Hip
• Arthroplasty, Replacement, Knee
• Antibiotic Prophylaxis

Interventions

• Single shot antibiotic prophylaxis
• Multiple shot antibiotic prophylaxis

Primary outcomes

• Revision arthroplasty because of infection — one year
  Revision of the hip or knee prosthesis because of infection within one year after primary surgery

Countries

Netherlands