Who is sponsoring NCT03341923?

NCT03341923 is sponsored by Alcon Research.

What drugs are being tested in NCT03341923?

Interventions in NCT03341923: Delefilcon A multifocal contact lenses, Etafilcon A multifocal contact lenses.

What condition does NCT03341923 study?

NCT03341923 studies Refractive Error, Presbyopia.

Is NCT03341923 still recruiting?

NCT03341923 is currently completed. Last updated 16 April 2019.

Are results published for NCT03341923?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2019-04-16 · How we verify

NCT03341923

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Evaluation of DAILIES TOTAL 1® Multifocal Compared to 1-Day Acuvue® Moist® Multifocal in a Japanese Population

Completed NA Results posted Last updated 16 April 2019

What this trial tests

NA trial testing Delefilcon A multifocal contact lenses in Refractive Error in 151 participants. Completed in 5 June 2018.

Timeline

20 December 2017

Primary endpoint
5 June 2018

5 June 2018

Quick facts

Lead sponsor	Alcon Research
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	151
Start date	20 December 2017
Primary completion	5 June 2018
Estimated completion	5 June 2018
Sites	4 locations across Japan

Drugs / interventions tested

Delefilcon A multifocal contact lenses
Etafilcon A multifocal contact lenses

Conditions studied

Refractive Error — all drugs for Refractive Error →
Presbyopia — all drugs for Presbyopia →

Sponsor

Alcon Research — full company profile →

Who can join

40 and older, any sex, with Refractive Error or Presbyopia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Percentage of Subjects With Investigator-graded Lens Centration of "Optimal" Primary · Day 14, each product

Lens centration was assessed by slit-lamp microscopy and graded on a 5-point scale, where 0=Optimal/Centered and 4=Severe decentration (with corneal exposure). One target eye was randomly selected for analysis.

Group	Value	95% CI
DT1MF	97.0
AMMF	91.0

Adverse events — posted to ClinicalTrials.gov

Time frame: Baseline through study completion, an average of 28 days. Reporting threshold: 5%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

DT1MF Ocular

Serious: 0/266 (0%)

Deaths: 0/266

DT1MF Systemic

Serious: 0/133 (0%)

Deaths: 0/133

AMMF Ocular

Serious: 0/268 (0%)

Deaths: 0/268

AMMF Systemic

Serious: 0/134 (0%)

Deaths: 0/134

Other adverse events (4 terms — click to expand)

Reaction	System	DT1MF Ocular	DT1MF Systemic	AMMF Ocular	AMMF Systemic
Visual impairment	Eye disorders	—	—	—	—
Asthenopia	Eye disorders	—	—	—	—
Dry eye	Eye disorders	—	—	—	—
Ocular discomfort	Eye disorders	—	—	—	—

Data from ClinicalTrials.gov NCT03341923 adverse events section.

Sponsor's own description

The purpose of this clinical study is to evaluate DAILIES TOTAL1® Multifocal (DT1MF) contact lenses compared to 1-DAY ACUVUE® Moist® Multifocal (AMMF) contact lenses for investigator-graded lens centration in a Japanese population.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Silicone hydrogel versus hydrogel soft contact lenses for differences in patient-reported eye comfort and safety.
Haworth K, Travis D, Leslie L, Fuller D, et al · · 2023 · cited 10× · PMID 37724689 · DOI 10.1002/14651858.cd014791.pub2

Verify or expand the search:

Other trials of Delefilcon A multifocal contact lenses

Trials testing the same drug.

NCT03118934 — Assessing Fitting Guides in Alcon Multifocal Contact Lenses · NA · completed
NCT02871375 — Clinical Assessment of DAILIES TOTAL1® (DT1) Multifocal · NA · completed

Other recruiting trials for Refractive Error

Currently open trials in the same condition.

NCT07354945 — An Evaluation of Myopia Control Lenses on Wearing Experience in Myopic Children · NA · recruiting

Other Alcon Research trials

Trials by the same sponsor.

NCT06884202 — Evaluation of Delefilcon A Contact Lenses · NA · completed
NCT06784063 — Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs) · NA · completed
NCT06571656 — Evaluation of the Safety and Tolerability of Ocular Lubricants · NA · terminated
NCT06660290 — A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes · Phase 3 · completed
NCT06483113 — DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03341923 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Alcon Research
Last refreshed: 16 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03341923.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing