NCT03341897

Varicocele Treatement by Endovasculer Embolization

Status unknown NA Last updated 15 February 2021

What this trial tests

NA trial testing endovasculer embolization of varicocele in Varicocele in 20 participants. Status unknown.

Timeline

1 June 2021

Primary endpoint
1 June 2021

1 October 2021

Quick facts

Lead sponsor	Assiut University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	1 June 2021
Primary completion	1 June 2021
Estimated completion	1 October 2021

Drugs / interventions tested

• endovasculer embolization of varicocele

Conditions studied

• Varicocele — all drugs for Varicocele →

Sponsor

Assiut University

Who can join

Adults 18 to 40, male only, with Varicocele. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A varicocele is a collection of varicose veins within the pampiniform (spermatic) plexus secondary to reflux in the internal spermatic vein (ISV).The condition affects 10% to 15% of the general population but is detected in as many as 40% of men undergoing an infertility workup. Depending on the method used for diagnosis, varicoceles are reported as bilateral in 17% to 77% of men. Traditionally, the diagnosis was made through clinical examination; however,as with other venous reflux disorders, ultrasound has become the mainstay of diagnosis. The traditional indications for treatment include infertility in patients with appropriate semen abnormalities, chronic groin pain, testicular atrophy in adolescent varicoceles, and recurrent varicocele after previous repair. Other indications more recently described with variable strength of evidence include low serum testosterone (with or without erectile dysfunction), benign prostatic hypertrophy,enhancement of assisted fertility techniques, and recurrent first trimester pregnancy loss.Infertility affects 10% to 15% of men of reproductive age. In approximately 50%, a cause is not found. The proof that varicocele repair improves fertility remains elusive; however, there is general acceptance that treatment does improve abnormalities of semen production.The traditional measures to assess semen production are sperm motility,morphology, and total sperm count. However, sperm counts greatly vary from day to day in any individual patient, and these measures correlate poorly with infertility outcomes.

The investigators do this study to evaluate the effectiveness of endovascular therapy using coils and other sclerosing agents and compare their results with other traditonal surgical methods in treatement of varicocele.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Surgical or radiological treatment for varicoceles in subfertile men.
   Persad E, O'Loughlin CA, Kaur S, Wagner G, et al · · 2021 · cited 35× · PMID 33890288 · DOI 10.1002/14651858.cd000479.pub6