Genes-in-Action - Hepcidin Regulation of Iron Supplementation

NCT03341338 COMPLETED

Anaemia continues to be one of the most common health problems affecting children and pregnant women in low-income countries. Nutritional iron deficiency is believed to be the main driver of anaemia, so mass iron supplementation and food fortification programs have been recommended by most public health organizations. However, these interventions are frequently ineffective and new strategies are desperately needed. Both anaemia and iron absorption are influenced by multiple factors, including nutritional status, infection, low grade inflammation and host genetics. The discovery of hepcidin, the master regulator of iron absorption and regulation has opened new avenues for investigation. Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) within hepcidin regulatory genes that are associated with altered iron status both in African populations. The study aims to investigate the impact of genetic alterations in hepcidin regulation on oral iron absorption. A recall-by-genotype study will be conducted using an existing database of pre-genotype individuals in rural Gambia (West Kiang). This database comprise of data on \>3000 Gambians, with Illumina HumanExome array data on 80K directly genotyped putative functional variants as well as imputation data on 20M variants.

Details

Lead sponsor	London School of Hygiene and Tropical Medicine
Status	COMPLETED
Enrolment	206
Start date	Mon Sep 05 2016 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Apr 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Anemia

Countries

The Gambia