Last reviewed · How we verify
Effects of Erythropoietin for Cognitive Side-effects of ECT (EPO-T)
EPO-T aims to investigate (i) whether short-term add-on treatment with erythropoietin (EPO) can reduce cognitive side-effects of ECT and (ii) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO. Finally, the trial examines whether potential protective effects of EPO on cognition are accompanied by changes in markers of oxidative stress, inflammation, and neuroplasticity. It is hypothesized that EPO treatment will (i) counteract ECT-induced cognitive decline, accompanied by (ii) increased sub-regional hippocampal volume, (iii) greater memory-related hippocampal activation and reinforcement of dorsolateral prefrontal activity during memory encoding and working memory, and (iv) changes in peripheral markers of inflammation, oxidative stress and neuroplasticity. Furthermore, we hypothesize that add-on EPO-treatment will produce greater, more sustained mood improvement than ECT treatment alone.
Details
| Lead sponsor | Martin Balslev Jørgensen |
|---|---|
| Phase | PHASE2 |
| Status | COMPLETED |
| Enrolment | 60 |
| Start date | Mon Jun 26 2017 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Feb 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- ECT
- Cognitive Impairment
- Unipolar Depression
- Bipolar Depression
Interventions
- Erythropoietin
- Saline
Countries
Denmark