NCT03339154

Metabolic Availability of Methionine From Chickpeas in Adult Men

Completed NA Last updated 13 November 2018

What this trial tests

NA trial testing Dietary Intakes in Healthy in 6 participants. Completed in 4 September 2018.

Timeline

4 August 2017

Primary endpoint
4 August 2018

4 September 2018

Quick facts

Lead sponsor	The Hospital for Sick Children
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	6
Start date	4 August 2017
Primary completion	4 August 2018
Estimated completion	4 September 2018
Sites	1 location across Canada

Drugs / interventions tested

• Dietary Intakes

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

The Hospital for Sick Children

Who can join

Adults 18 to 49, male only, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The research study is being done so we can determine the quality of the protein present in Canadian chickpeas. Amino acids are the building blocks of protein and protein quality is determined by the amount of amino acids present and by their bioavailability (their absorption and use by the body). Some amino acids are essential which means they must be obtained from the diet. If any one of the essential amino acids is missing in the diet, the body cannot make proteins that are used to repair tissue build bone, teeth, etc…Chickpeas as a food source contain low amounts of the essential amino acid methionine which makes its protein incomplete. The amino acids in chickpeas are also affected by cooking. Our objective is to determine the amount of methionine in chickpeas that the body can use. We will test chickpeas by studying them after cooking them, on their own and by combining the chickpeas with rice in a mixed meal to make a more complete protein.

This research is being done in order to bridge the gap between knowledge of protein requirement and the amount of food needed to meet that requirement. Results from this study will be important for recommendations guiding food choices of chickpeas as a major protein source in the diet.

Previously the quality of dietary protein for human consumption was studied in animals. This study is being done in humans because studies in animals are not directly applicable to humans. Excessive animal protein consumption is also linked to cardiovascular disease. Plant protein sources like chickpeas are important alternatives shown to "enhance ecosystem resilience, and improve human health.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Bioavailable Methionine Assessed Using the Indicator Amino Acid Oxidation Method Is Greater When Cooked Chickpeas and Steamed Rice Are Combined in Healthy Young Men.
   Rafii M, Pencharz PB, Ball RO, Tomlinson C, et al · · 2020 · cited 23× · PMID 32271919 · DOI 10.1093/jn/nxaa086