Who is sponsoring NCT03339037?

NCT03339037 is sponsored by Assaf-Harofeh Medical Center.

What drugs are being tested in NCT03339037?

Interventions in NCT03339037: Hyperbaric oxygen therapy, Normobaric air SHAM.

What condition does NCT03339037 study?

NCT03339037 studies Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome.

Is NCT03339037 still recruiting?

NCT03339037 is currently terminated. Last updated 3 July 2024.

Last reviewed 2024-07-03 · How we verify

NCT03339037: TBIPED

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children

Terminated NA Last updated 3 July 2024

What this trial tests

NA trial testing Hyperbaric oxygen therapy in Hyperbaric Oxygen Therapy in 52 participants. Terminated before completion.

Timeline

1 November 2017

Primary endpoint
1 November 2021

20 May 2022

Quick facts

Lead sponsor	Assaf-Harofeh Medical Center
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	52
Start date	1 November 2017
Primary completion	1 November 2021
Estimated completion	20 May 2022
Sites	1 location across Israel

Drugs / interventions tested

Hyperbaric oxygen therapy — full drug profile →
Normobaric air SHAM

Conditions studied

Hyperbaric Oxygen Therapy — all drugs for Hyperbaric Oxygen Therapy →
Traumatic Brain Injury — all drugs for Traumatic Brain Injury →
Post-Concussion Syndrome — all drugs for Post-Concussion Syndrome →

Sponsor

Assaf-Harofeh Medical Center

Who can join

Adults 8 to 16, any sex, with Hyperbaric Oxygen Therapy or Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics. Relying on its results in adults, HBOT offers a promising new direction of treatment, which targets the basic pathological processes responsible for post-concussion symptoms. The effect of hyperbaric oxygen therapy in pediatric TBI has never been evaluated. The aim of the current study is to evaluate in a prospective cross-over, randomized study, the effect of HBOT on children with PPCS due to mild TBI.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial.
Hadanny A, Catalogna M, Yaniv S, Stolar O, et al · · 2022 · cited 17× · PMID 36151105 · DOI 10.1038/s41598-022-19395-y

Verify or expand the search:

Other trials of Hyperbaric oxygen therapy

Trials testing the same drug.

NCT06806345 — Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopause · Phase 1, PHASE2 · recruiting
NCT06619808 — Hyperbaric Oxygen Therapy for Metabolic Dysfunction-associated Steatotic Liver Diseases · NA · recruiting
NCT05980195 — Cognitive Improvement After Carotid Stenting in Hyperbaric Oxygen Therapy Trial · NA · not yet recruiting
NCT06954376 — Hyperbaric Oxygen Therapy as a Neuroprotective Intervention in Pediatric Acquired Brain Injury With Cognitive Disability · NA · completed
NCT06954389 — Hyperbaric Oxygen Therapy as a Neuroprotective Modality in Pediatric Acquired Brain Injury With Motor Disability · NA · completed

Other recruiting trials for Hyperbaric Oxygen Therapy

Currently open trials in the same condition.

NCT03144206 — Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study · Phase 4 · active not recruiting

Other Assaf-Harofeh Medical Center trials

Trials by the same sponsor.

NCT07334639 — Metabolic Changes Associated With Weight Gain After Treatment of Achalasia · not yet recruiting
NCT07276334 — Same Day Discharge Vs. Hospitalization for Operative Fixation of Distal Radius Fractures · NA · enrolling by invitation
NCT07231900 — Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients · Phase 2, PHASE3 · not yet recruiting
NCT07252180 — Comparing Two Different Methods of Ablation of Inlet Patches (APC vs RFA) · NA · active not recruiting
NCT04664790 — Hyperbaric Oxygen Therapy Compared to Cognitive Training in FASD · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03339037 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Assaf-Harofeh Medical Center
Last refreshed: 3 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03339037.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing