NCT03334526

Study of the Reaction of the Brain to Various Stimulations

Completed NA Last updated 16 February 2023

What this trial tests

NA trial testing physical training in Corticospinal Plasticity in 174 participants. Completed in 24 June 2022.

Timeline

9 November 2017

Primary endpoint
24 June 2022

24 June 2022

Quick facts

Lead sponsor	Centre Hospitalier Universitaire Dijon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	174
Start date	9 November 2017
Primary completion	24 June 2022
Estimated completion	24 June 2022
Sites	1 location across France

Drugs / interventions tested

• physical training
• mental training
• electrical stimulation

Conditions studied

• Corticospinal Plasticity — all drugs for Corticospinal Plasticity →
• Neuromuscular Plasticity — all drugs for Neuromuscular Plasticity →

Sponsor

Centre Hospitalier Universitaire Dijon

Who can join

Adults 18 to 60, any sex, with Corticospinal Plasticity or Neuromuscular Plasticity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. An acute session of motor imagery training induces use-dependent plasticity.
   Ruffino C, Gaveau J, Papaxanthis C, Lebon F. · · 2019 · cited 37× · PMID 31882851 · DOI 10.1038/s41598-019-56628-z
2. Explicit and implicit motor simulations are impaired in individuals with aphantasia.
   Dupont W, Papaxanthis C, Madden-Lombardi C, Lebon F. · · 2024 · cited 19× · PMID 38515440 · DOI 10.1093/braincomms/fcae072
3. Insights into the combination of neuromuscular electrical stimulation and motor imagery in a training-based approach.
   Bouguetoch A, Martin A, Grosprêtre S. · · 2021 · cited 17× · PMID 33417035 · DOI 10.1007/s00421-020-04582-4
4. Influence of Voluntary Contraction Level, Test Stimulus Intensity and Normalization Procedures on the Evaluation of Short-Interval Intracortical Inhibition.
   Neige C, Grosprêtre S, Martin A, Lebon F. · · 2020 · cited 11× · PMID 32650395 · DOI 10.3390/brainsci10070433
5. Optimal stimulation parameters for spinal and corticospinal excitabilities during contraction, motor imagery and rest: A pilot study.
   Bouguetoch A, Grosprêtre S, Martin A. · · 2020 · cited 11× · PMID 32569326 · DOI 10.1371/journal.pone.0235074
6. Mental practice modulates functional connectivity between the cerebellum and the primary motor cortex.
   Rannaud Monany D, Lebon F, Dupont W, Papaxanthis C. · · 2022 · cited 7× · PMID 35637729 · DOI 10.1016/j.isci.2022.104397
7. Effect of the Knee and Hip Angles on Knee Extensor Torque: Neural, Architectural, and Mechanical Considerations.
   Garnier YM, Lepers R, Canepa P, Martin A, et al · · 2021 · cited 7× · PMID 35058798 · DOI 10.3389/fphys.2021.789867
8. The impact of submaximal fatiguing exercises on the ability to generate and sustain the maximal voluntary contraction.
   Lebesque L, Scaglioni G, Martin A. · · 2022 · cited 4× · PMID 36117706 · DOI 10.3389/fphys.2022.970917