NCT03334357: FIT-AGING

Physical Fitness as Klotho Protein Stimulator.

Completed NA Last updated 12 October 2018

What this trial tests

NA trial testing PAR in Physical Activity in 74 participants. Completed in 23 December 2017.

Timeline

1 June 2016

Primary endpoint
23 December 2017

23 December 2017

Quick facts

Lead sponsor	Manuel Castillo Garzón
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	74
Start date	1 June 2016
Primary completion	23 December 2017
Estimated completion	23 December 2017

Drugs / interventions tested

• PAR
• HIIT
• WB-EMS

Conditions studied

• Physical Activity — all drugs for Physical Activity →
• Aging — all drugs for Aging →

Sponsor

Manuel Castillo Garzón

Who can join

Adults 40 to 65, any sex, with Physical Activity or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

FIT-AGING will determine the effect of different exercise modalities on α-Klotho protein (primary outcome) in sedentary healthy adults. FIT-AGING also investigate the physiological consequences of activating Klotho gene (secondary outcomes).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology.
   Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L, Espuch-Oliver A, et al · · 2018 · cited 56× · PMID 30023455 · DOI 10.1016/j.conctc.2018.05.013
2. Impact of Using Different Levels of Threshold-Based Artefact Correction on the Quantification of Heart Rate Variability in Three Independent Human Cohorts.
   Alcantara JMA, Plaza-Florido A, Amaro-Gahete FJ, Acosta FM, et al · · 2020 · cited 53× · PMID 31979367 · DOI 10.3390/jcm9020325
3. Changes in Physical Fitness After 12 Weeks of Structured Concurrent Exercise Training, High Intensity Interval Training, or Whole-Body Electromyostimulation Training in Sedentary Middle-Aged Adults: A Randomized Controlled Trial.
   Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L, Dote-Montero M, et al · · 2019 · cited 37× · PMID 31105580 · DOI 10.3389/fphys.2019.00451
4. Inter- and intra-researcher reproducibility of heart rate variability parameters in three human cohorts.
   Plaza-Florido A, Alcantara JMA, Migueles JH, Amaro-Gahete FJ, et al · · 2020 · cited 31× · PMID 32647148 · DOI 10.1038/s41598-020-68197-7
5. Accuracy and Validity of Resting Energy Expenditure Predictive Equations in Middle-Aged Adults.
   Amaro-Gahete FJ, Jurado-Fasoli L, De-la-O A, De-la-O A, et al · · 2018 · cited 31× · PMID 30400196 · DOI 10.3390/nu10111635
6. Role of physical activity and fitness on sleep in sedentary middle-aged adults: the FIT-AGEING study.
   Mochón-Benguigui S, Carneiro-Barrera A, Castillo MJ, Amaro-Gahete FJ. · · 2021 · cited 26× · PMID 33436671 · DOI 10.1038/s41598-020-79355-2
7. Association between Sleep Quality and Body Composition in Sedentary Middle-Aged Adults.
   Jurado-Fasoli L, Amaro-Gahete FJ, De-la-O A, Dote-Montero M, et al · · 2018 · cited 26× · PMID 30463242 · DOI 10.3390/medicina54050091
8. Relationship between plasma S-Klotho and cardiometabolic risk in sedentary adults.
   Amaro-Gahete FJ, Jurado-Fasoli L, Sanchez-Delgado G, García-Lario JV, et al · · 2020 · cited 22× · PMID 31958773 · DOI 10.18632/aging.102771