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Mechanism of Decompensation Evaluation - Aortic Stenosis (MODE-AS)
Aortic stenosis is the most common heart valve disease requiring intervention in high income countries. It is characterised by progressive valvular thickening, and restriction as well is hypertrophy and fibrosis of the left ventricle in response to pressure overload. The pathological processes in the left ventricle that ultimately result in heart failure and death are incompletely understood. Further elucidation of these processes and how they correlate with novel blood biomarkers may help us design new treatments and optimise the timing of surgical intervention. In brief, recruited patients with severe aortic stenosis and scheduled to undergo valve replacement surgery will be invited for some simple tests (blood sampling, ECG, echocardiogram). A septal myocardial biopsy will be taken at the time of surgery and the disease valve retained. These will be examined histologically and pathological changes compared with results obtained from ECG, echocardiogram and blood tests.
Details
| Lead sponsor | University of Edinburgh |
|---|---|
| Status | COMPLETED |
| Enrolment | 90 |
| Start date | Mon Sep 03 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Jul 31 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Aortic Stenosis
- Myocardial Fibrosis
- Left Ventricular Hypertrophy
Countries
United Kingdom