NCT03330379 (CONTIPRESS) is a NA clinical trial of Tracoe Smart CuffmanagerTM in Acute Brain Injury, sponsored by Nantes University Hospital.

Who is sponsoring NCT03330379?

NCT03330379 is sponsored by Nantes University Hospital.

What drugs are being tested in NCT03330379?

Interventions in NCT03330379: Tracoe Smart CuffmanagerTM.

What condition does NCT03330379 study?

NCT03330379 studies Acute Brain Injury, Brain Injuries.

Is NCT03330379 still recruiting?

NCT03330379 is currently completed. Last updated 4 September 2019.

Last reviewed 2019-09-04 · How we verify

NCT03330379: CONTIPRESS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Two Strategies for Endotracheal Tube Cuff Underinflation Prevention During Invasive Mechanical Ventilation

Completed NA Last updated 4 September 2019

What this trial tests

NA trial testing Tracoe Smart CuffmanagerTM in Acute Brain Injury in 60 participants. Completed in 31 July 2019.

Timeline

1 March 2018

Primary endpoint
31 July 2019

31 July 2019

Quick facts

Lead sponsor	Nantes University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	60
Start date	1 March 2018
Primary completion	31 July 2019
Estimated completion	31 July 2019
Sites	1 location across France

Drugs / interventions tested

Tracoe Smart CuffmanagerTM

Conditions studied

Acute Brain Injury — all drugs for Acute Brain Injury →
Brain Injuries — all drugs for Brain Injuries →

Sponsor

Nantes University Hospital

Who can join

18 and older, any sex, with Acute Brain Injury or Brain Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

During invasive mechanical ventilation, maintaining endotracheal tube cuff pressure (Pcuff) around 25 cmH2O is recommended for sealing the upper airways. The continuous control of Pcuff with a simple mechanical device, the Tracoe Smart CuffmanagerTM, has never been assessed. The investigators hypothesize that the Tracoe Smart CuffmanagerTM would allow a reduction of the incidence of underinflation episodes, as compared with the intermittent strategy of Pcuff control.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Automatic regulation of the endotracheal tube cuff pressure with a portable elastomeric device. A randomised controlled study.
Dauvergne JE, Geffray AL, Asehnoune K, Rozec B, et al · · 2020 · cited 13× · PMID 32376293 · DOI 10.1016/j.accpm.2020.04.007

Verify or expand the search:

Other recruiting trials for Acute Brain Injury

Currently open trials in the same condition.

NCT07380477 — VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site · recruiting
NCT06542107 — Weaning From Mechanical Ventilation in Patients With Acute Brain Injury · recruiting
NCT06469801 — ECMO ABI Detection With Hyperfine · NA · recruiting
NCT06426615 — Connectivity and Neural Signatures of Consciousness in Unresponsive States · NA · recruiting
NCT04080440 — Brain-injured Patients Extubation Readiness Study · NA · recruiting

Other Nantes University Hospital trials

Trials by the same sponsor.

NCT07278661 — Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery. · Phase 2 · recruiting
NCT06681363 — Creation of a Biocollection of Patients With Acute Myeloid Leukemia (AML) or Lymphoid Leukemia (ALL) or High-risk Myelod · not yet recruiting
NCT07467382 — GOAT (Gait Observation of Achilles Tendon) · not yet recruiting
NCT07490379 — Comparison of the Efficacy of Transcranial Direct Current Stimulation at Home Versus in Hospital Settings in Patients Wi · NA · not yet recruiting
NCT07423481 — Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03330379 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Nantes University Hospital
Last refreshed: 4 September 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03330379.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing