NCT03322553 is a NA clinical trial of GERD-X in Gastro Esophageal Reflux Disease, sponsored by Asian Institute of Gastroenterology, India.

Who is sponsoring NCT03322553?

NCT03322553 is sponsored by Asian Institute of Gastroenterology, India.

What drugs are being tested in NCT03322553?

Interventions in NCT03322553: GERD-X.

What condition does NCT03322553 study?

NCT03322553 studies Gastro Esophageal Reflux Disease.

Is NCT03322553 still recruiting?

NCT03322553 is currently completed. Last updated 22 January 2020.

Last reviewed 2020-01-22 · How we verify

NCT03322553

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Endoscopic Full Thickness Plication (GERD-X) for the Treatment of PPI Dependent GERD:

Completed NA Last updated 22 January 2020

What this trial tests

NA trial testing GERD-X in Gastro Esophageal Reflux Disease in 70 participants. Completed in 30 December 2019.

Timeline

15 November 2017

Primary endpoint
30 August 2019

30 December 2019

Quick facts

Lead sponsor	Asian Institute of Gastroenterology, India
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	70
Start date	15 November 2017
Primary completion	30 August 2019
Estimated completion	30 December 2019
Sites	1 location across India

Drugs / interventions tested

GERD-X

Conditions studied

Gastro Esophageal Reflux Disease — all drugs for Gastro Esophageal Reflux Disease →

Sponsor

Asian Institute of Gastroenterology, India

Who can join

Adults 18 to 60, any sex, with Gastro Esophageal Reflux Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Gastro-esophageal reflux disease (GERD) is a common gastrointestinal disorder with a significant proportion of patients becoming dependent on proton pump inhibitor (PPI) therapy. Long term use of PPI therapy can be associated with side effects such as osteoporosis, small intestinal bacterial overgrowth and renal failure. Moreover, some of the patients might be reluctant to take PPIs for long duration and prefer surgery over pharmacotherapy. Endoscopic plication (GERD-X) is an alternative and less invasive procedure compared to laparoscopic fundoplication for the treatment of GERD. In endoscopic plication, transmural sutures are applied at the gastro-esophageal (GE) junction thereby reconstructing the gastric cardia and accentuating the valvular mechanism to prevent reflux. Only few trials have evaluated the efficacy of endoscopic plication technique and reported encouraging results. In this study we aim to evaluate the efficacy of a similar endoscopic technique but with application of two transmural sutures in randomized controlled method.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial.
Kalapala R, Karyampudi A, Nabi Z, Darisetty S, et al · · 2022 · cited 39× · PMID 33849942 · DOI 10.1136/gutjnl-2020-321811
Systematic mapping of registered interventional studies addressing the top 10 research priorities in Barrett's oesophagus and gastro-oesophageal reflux disease.
Gamakaranage C, Ratcliffe E, Britton J, Butler T, et al · · 2025 · PMID 40527525 · DOI 10.1136/bmjgast-2025-001738

Verify or expand the search:

Other recruiting trials for Gastro Esophageal Reflux Disease

Currently open trials in the same condition.

NCT06693622 — Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests · recruiting
NCT06564558 — The Effect of Postural Correction On Gastroesophageal Reflux Disease · NA · recruiting

Other Asian Institute of Gastroenterology, India trials

Trials by the same sponsor.

NCT07486518 — A Multicentre Prospective Cohort Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy An · not yet recruiting
NCT07413822 — A Single-centre Open, Prospective, Pilot Clinical Study to Assess the Safety and Performance of the TIES® Transcutaneous · NA · not yet recruiting
NCT07399652 — Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures · NA · recruiting
NCT07371832 — A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colo · recruiting
NCT07329816 — External, Multicentre Validation of a Machine-Learning Model to Predict Colonic Adenoma in Indian Adults · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03322553 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Asian Institute of Gastroenterology, India
Last refreshed: 22 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03322553.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing