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NCT03321799
Comparison of Negative Pressure Wound Therapy vs. Conventional Dressings for Prevention of Wound Complications After Revision THA
Phase 1 trial testing Negative Pressure Wound Therapy (NPWT) in Infection, Drainage in 201 participants. Completed in 11 July 2025.
14 March 2024
Quick facts
| Lead sponsor | Rush University Medical Center |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 201 |
| Start date | 28 April 2017 |
| Primary completion | 14 March 2024 |
| Estimated completion | 11 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Negative Pressure Wound Therapy (NPWT)
- Sterile Antimicrobial Dressings
Conditions studied
- Infection, Drainage — all drugs for Infection, Drainage →
Sponsor
Rush University Medical Center
Who can join
18 and older, any sex, with Infection, Drainage. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Wound complications and surgical site infections following revision total joint arthroplasty result in significant morbidity and cost. To the investigators knowledge, no prospective, randomized controlled trials have examined the rate of wound complications, infection, and reoperation following revision total hip arthroplasty when treated with negative pressure wound therapy (NPWT) versus sterile dressings. The investigators hypothesize that the rate of wound complications, infections, and subsequent procedures in patients undergoing revision THA treatment will demonstrate a statistically and clinically relevant decrease when using NPWT versus sterile dressing.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Negative pressure wound therapy for surgical wounds healing by primary closure.
Webster J, Liu Z, Norman G, Dumville JC, et al · · 2019 · cited 73× · PMID 30912582 · DOI 10.1002/14651858.cd009261.pub4 -
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Shi C, Goh EL, Murphy EM, et al · · 2022 · cited 71× · PMID 35471497 · DOI 10.1002/14651858.cd009261.pub7 -
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 48× · PMID 32542647 · DOI 10.1002/14651858.cd009261.pub6 -
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 38× · PMID 32356396 · DOI 10.1002/14651858.cd009261.pub5
Verify or expand the search:
- PubMed search for NCT03321799
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Negative Pressure Wound Therapy (NPWT)
Trials testing the same drug.
- NCT07040683 — Negative Pressure Wound Therapy for Split Thickness Skin Grafting to the Lower Leg After Excision of Skin Tumour: A Mult · NA · not yet recruiting
- NCT03345771 — Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthrop · Phase 3 · completed
Other Rush University Medical Center trials
Trials by the same sponsor.
- NCT07278076 — Clinical Decision-Making During FEES: The Impact of Residue Amount and Location · NA · not yet recruiting
- NCT07088120 — PRECISION-CPR: PRecision-Controlled Ventilation in CPR · NA · not yet recruiting
- NCT06894719 — Oral Tranexamic Acid After Total Knee Arthroplasty · Phase 4 · not yet recruiting
- NCT06229392 — A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer · Phase 1 · withdrawn
- NCT07452406 — Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03321799 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rush University Medical Center
- Last refreshed: 6 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03321799.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing