NCT03321682

Cardiopulmonary Capacity and Quality of Life in Patients With Chronic Heart Failure

Completed NA Last updated 12 July 2022

What this trial tests

NA trial testing Functional Training in Heart Failure in 38 participants. Completed in 30 November 2020.

Timeline

6 March 2017

Primary endpoint
1 September 2020

30 November 2020

Quick facts

Lead sponsor	Hospital de Clinicas de Porto Alegre
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	38
Start date	6 March 2017
Primary completion	1 September 2020
Estimated completion	30 November 2020
Sites	1 location across Brazil

Drugs / interventions tested

• Functional Training
• Strength Training

Conditions studied

• Heart Failure — all drugs for Heart Failure →

Sponsor

Hospital de Clinicas de Porto Alegre

Who can join

18 and older, any sex, with Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Heart Failure is a progressive disorder that begins after an insult to the heart muscle resulting in the loss of functional cardiomyocytes, or even compromising the ability of the myocardium to contract and/or relax normally. A common finding in heart failure is exercise intolerance that generates a vicious cycle, in which the individual starts to limit his activities even further due to progressive fatigue. Studies demonstrate that regular physical exercise can increase the aerobic capacity of these individuals, delay the anaerobic threshold, and reestablish the sympathovagal balance. Paradoxically, many of these patients assume an even more sedentary lifestyle, which leads to a greater physical limitation and the progression of symptoms. Patients with heart failure present a 30% reduction in their ability to perform their daily life activities when compared to healthy individuals, and this has also been attributed to reduced muscle mass, as well as lower aerobic capacity. In this sense, strength training increases the torque and muscular endurance, capacity and functional independence, as well as the quality of life, reducing the morbidity of individuals with and without cardiovascular disease, with a lower overload to the cardiorespiratory system. It is known, however, that daily life activities require a combination of resistance and muscle strength. Aerobic training does not improve muscle strength, just as traditional strength training does not ideally represent the movements performed during daily life activities, since it does not include exercises on unstable surfaces and exercises on different axes. Functional training emerges as a simple and low cost alternative for the treatment of patients with heart failure. This method consists of integrated movements of the body, in several axes, involving joint acceleration and deceleration, stabilization, strength and neuromuscular efficiency. It aims to improve the functional capacity of the individual using exercises that relate to their specific physical activity, transferring their gains effectively to their daily lives. The aim of the present study is to evaluate the effects of functional training on cardiopulmonary capacity and quality of life in patients with heart failure, comparing it to strength training.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Cardiopulmonary exercise capacity and quality of life of patients with heart failure undergoing a functional training program: study protocol for a randomized clinical trial.
   do Nascimento DM, Machado KC, Bock PM, Saffi MAL, et al · · 2020 · cited 6× · PMID 32334527 · DOI 10.1186/s12872-020-01481-6
2. Functional training improves peak oxygen consumption and quality of life of individuals with heart failure: a randomized clinical trial.
   do Nascimento DM, Machado KC, Bock PM, Saffi MAL, et al · · 2023 · cited 3× · PMID 37516830 · DOI 10.1186/s12872-023-03404-7