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NCT03321370
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
trial testing Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention in Traumatic Brain Injury in 10 participants. Currently enrolling.
1 November 2025
Quick facts
| Lead sponsor | Hennepin County Medical Center, Minneapolis |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 14 August 2019 |
| Primary completion | 1 November 2025 |
| Estimated completion | 1 November 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
Conditions studied
- Traumatic Brain Injury — all drugs for Traumatic Brain Injury →
Sponsor
Hennepin County Medical Center, Minneapolis
Who can join
18 and older, any sex, with Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Mapping spreading depolarisations after traumatic brain injury: a pilot clinical study protocol.
Cramer SW, Pino IP, Naik A, Carlson D, et al · · 2022 · cited 1× · PMID 35831043 · DOI 10.1136/bmjopen-2022-061663
Verify or expand the search:
- PubMed search for NCT03321370
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Hennepin County Medical Center, Minneapolis trials
Trials by the same sponsor.
- NCT03762317 — Clonidine as Adjunct to Morphine for Neonatal Abstinence Syndrome · Phase 4 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03321370 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hennepin County Medical Center, Minneapolis
- Last refreshed: 12 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03321370.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing