NCT03319303

What Effect Does Intubation Have on Regional Lung Ventilation?

Completed Last updated 2 July 2018

What this trial tests

trial in Anesthesia in 10 participants. Completed in 31 March 2018.

Timeline

20 October 2017

Primary endpoint
31 March 2018

31 March 2018

Quick facts

Lead sponsor	The Leeds Teaching Hospitals NHS Trust
Status	Completed
Study type	OBSERVATIONAL
Enrollment	10
Start date	20 October 2017
Primary completion	31 March 2018
Estimated completion	31 March 2018
Sites	1 location across United Kingdom

Conditions studied

• Anesthesia — all drugs for Anesthesia →

Sponsor

The Leeds Teaching Hospitals NHS Trust

Who can join

Adults 16 to 100, any sex, with Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

During any general anaesthetic which involves muscle relaxation artificial breathing is required. This is most commonly provided by pushing air under pressure (positive pressure ventilation) into the lungs via a tube in the airway (the tracheal tube). It has been observed for many years that with this form of breathing the distribution of gas within the lungs differs from that seen during 'natural' breathing: more of the gas goes to the upper parts of the lung than lower parts. This change in how the gas is distributed can lead to problems with how well oxygen is taken up by blood and carbon dioxide removed from the body. Previous work using mathematical modelling has found that the position of the tracheal tube might affect air distribution, but this has previously been difficult to study in 'real life', requiring the use of radioactive dyes and computerised tomography (CT). However a bedside test is now available which allows us to study these changes rapidly and non-invasively, using electrical impedance tomography (EIT). The EIT device is commercially available (PulmoVista®, Draeger UK) and is used in hospitals worldwide as a bedside monitor of lung ventilation.

This study aims to investigate the effect of tracheal intubation on regional ventilation of the lungs by comparing measurements before and after the patient is anaesthetised and intubated. The investgiators aim to show whether altered patterns of ventilation are caused by patients simply being asleep and ventilated, or whether these changes are due to the use of a tracheal tube itself. The exact effect of tube position will also be studied by measuring ventilation as the tube is deliberately advanced until it enters one of the lungs. This will give us information about the ideal position for a tube within the trachea to promote optimal ventilation patterns within the lungs

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.