NCT03312309

Personal FET in RIF Patients According to Histological Dating of Endometrial of Natural/ Hormone Replacement Cycle

Completed NA Last updated 11 January 2022

What this trial tests

NA trial testing personal embryo transfer in Infertility, Female in 155 participants. Completed in 28 February 2018.

Timeline

17 October 2017

Primary endpoint
31 December 2017

28 February 2018

Quick facts

Lead sponsor	Reproductive & Genetic Hospital of CITIC-Xiangya
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	155
Start date	17 October 2017
Primary completion	31 December 2017
Estimated completion	28 February 2018
Sites	1 location across China

Drugs / interventions tested

• personal embryo transfer

Conditions studied

• Infertility, Female — all drugs for Infertility, Female →

Sponsor

Reproductive & Genetic Hospital of CITIC-Xiangya

Who can join

Adults 20 to 40, female only, with Infertility, Female. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

At present, the evaluation criterion of endometrial receptivity is controversial. The development of a molecular diagnostic tool, the endometrial receptivity array (ERA) for diagnosis of endometrial receptivity . But use of this test in patients with RIF has shown that the window of implantation (WOI) is displaced in only a quarter of these patients and use of a personalized embryo transfer (pET) on the day designated by ERA improves reproductive performance with higher cost .what is known to the others'population? The morphological changes observed on histology for each specific day after ovulation were described by Noyes and his colleagues in 1950 . An endometrial biopsy that shows a difference of more than 2 days between the histologic dating and actual day after ovulation is considered to be ''out of phase''. But such pET studies according to the Noyes criterion are lacking . The aim of this study is to explore the Personal frozen-thawed embryo transfer in unexplained RIF patients according to the blinded histological dating of endometrial biopsies .

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Clinical value of histologic endometrial dating for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles.
   Li Y, Li XF, Liao JN, Fan XX, et al · · 2020 · cited 10× · PMID 32917168 · DOI 10.1186/s12884-020-03217-y