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NCT03312036: HERCOLE
HEpatic Regeneration With COupled Plasma Filtration and Adsorption for Liver Extracorporeal Detoxification
NA trial testing Coupled plasma filtration and adsorption (CPFA) in Liver Failure, Acute in 12 participants. Completed in 21 December 2018.
21 December 2018
Quick facts
| Lead sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 12 |
| Start date | 6 June 2013 |
| Primary completion | 21 December 2018 |
| Estimated completion | 21 December 2018 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Coupled plasma filtration and adsorption (CPFA)
Conditions studied
- Liver Failure, Acute — all drugs for Liver Failure, Acute →
- Liver Failure, Acute on Chronic — all drugs for Liver Failure, Acute on Chronic →
Sponsor
IRCCS Azienda Ospedaliero-Universitaria di Bologna — full company profile →
Who can join
18 and older, any sex, with Liver Failure, Acute or Liver Failure, Acute on Chronic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
CPFA is currently used in the treatment of severe sepsis with the intention of removing the proinflammatory mediators from the systemic circulation. Some evidence exists about the bilirubin adsorbing ability of the neutral styrenic resin which is part of the extracorporeal circuit of CPFA. The aim of this study is to assess efficacy and safety of CPFA in extracorporeal detoxification of liver toxins in patients affected by acute or acute-on-chronic liver failure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Detoxification of bilirubin and bile acids with intermittent coupled plasmafiltration and adsorption in liver failure (HERCOLE study).
Donati G, Angeletti A, Gasperoni L, Piscaglia F, et al · · 2021 · cited 14× · PMID 32710265 · DOI 10.1007/s40620-020-00799-w
Verify or expand the search:
- PubMed search for NCT03312036
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03312036 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Last refreshed: 17 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03312036.
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