NCT03310060 is a Phase 4 clinical trial of Tisseel in Total Blood Loss, sponsored by Chang Gung Memorial Hospital.

Who is sponsoring NCT03310060?

NCT03310060 is sponsored by Chang Gung Memorial Hospital.

What drugs are being tested in NCT03310060?

Interventions in NCT03310060: Tisseel, Tranexamic Acid.

What condition does NCT03310060 study?

NCT03310060 studies Total Blood Loss.

Is NCT03310060 still recruiting?

NCT03310060 is currently status unknown. Last updated 16 October 2017.

Last reviewed 2017-10-16 · How we verify

NCT03310060

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Reducing Blood Loss Using Tisseel in TKA

Status unknown Phase 4 Last updated 16 October 2017

What this trial tests

Phase 4 trial testing Tisseel in Total Blood Loss in 100 participants. Status unknown.

Timeline

1 November 2017

Primary endpoint
31 August 2018

31 December 2018

Quick facts

Lead sponsor	Chang Gung Memorial Hospital
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	single
Primary purpose	prevention
Enrollment	100
Start date	1 November 2017
Primary completion	31 August 2018
Estimated completion	31 December 2018

Drugs / interventions tested

Tisseel — full drug profile →
Tranexamic Acid (Tranexamic Acid) — full drug profile →

Conditions studied

Total Blood Loss — all drugs for Total Blood Loss →

Sponsor

Chang Gung Memorial Hospital

Who can join

Adults 20 to 85, any sex, with Total Blood Loss. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of the topical hemostatic agents in patients receiving primary TKA procedures. The investigators will also observe if there is increased risk of blood transfusion rate by using topical hemostatic agents or not.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Application and outlook of topical hemostatic materials: a narrative review.
Zhong Y, Hu H, Min N, Wei Y, et al · · 2021 · cited 71× · PMID 33987275 · DOI 10.21037/atm-20-7160
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis.
Gibbs VN, Champaneria R, Sandercock J, Welton NJ, et al · · 2024 · cited 19× · PMID 38226724 · DOI 10.1002/14651858.cd013295.pub2
Topical Fibrin Sealant (Tisseel@) Does Not Provide a Synergic Blood-Conservation Effect with Tranexamic Acid in Total Knee Arthroplasty-A Prospective Randomized Controlled Trial.
Liu CH, Chang CH, Chang YH, Shih HN, et al · · 2023 · PMID 38138181 · DOI 10.3390/medicina59122078

Verify or expand the search:

Other trials of Tisseel

Trials testing the same drug.

NCT03733639 — Tisseel® as a Reinforcement of Esophagojejunal Anastomoses · Phase 4 · unknown
NCT02953145 — The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery · Phase 4 · withdrawn

Other Chang Gung Memorial Hospital trials

Trials by the same sponsor.

NCT07419789 — Precision Care for Older Persons · NA · not yet recruiting
NCT07248345 — Virtual Reality Intervention for Family Caregivers of Persons Living With Dementia · NA · not yet recruiting
NCT07036978 — Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer · not yet recruiting
NCT07489833 — Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue · not yet recruiting
NCT07496528 — The ACURE Trial: Acupuncture for Colorectal Recovery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03310060 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
Last refreshed: 16 October 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03310060.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing