NCT03310034: NADS

NAD Supplementation Study

Terminated NA Last updated 20 August 2020

What this trial tests

NA trial testing NAD-precursors in Aging in 14 participants. Terminated before completion.

Timeline

1 November 2017

Primary endpoint
6 March 2020

6 March 2020

Quick facts

Lead sponsor	Maastricht University
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	14
Start date	1 November 2017
Primary completion	6 March 2020
Estimated completion	6 March 2020
Sites	1 location across Netherlands

Drugs / interventions tested

• NAD-precursors
• Control

Conditions studied

• Aging — all drugs for Aging →
• Mitochondrial Function — all drugs for Mitochondrial Function →

Sponsor

Maastricht University

Who can join

Adults 65 to 75, any sex, with Aging or Mitochondrial Function. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromised, elderly humans. Outcomes are related to mitochondrial function, energy metabolism, and physical function will be investigated.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. NAD<sup>+</sup> metabolism and its roles in cellular processes during ageing.
   Covarrubias AJ, Perrone R, Grozio A, Verdin E. · · 2021 · cited 1089× · PMID 33353981 · DOI 10.1038/s41580-020-00313-x
2. NAD⁺ metabolism: pathophysiologic mechanisms and therapeutic potential.
   Xie N, Zhang L, Gao W, Huang C, et al · · 2020 · cited 744× · PMID 33028824 · DOI 10.1038/s41392-020-00311-7
3. NAD⁺ metabolism as a target for metabolic health: have we found the silver bullet?
   Connell NJ, Houtkooper RH, Schrauwen P. · · 2019 · cited 47× · PMID 30772929 · DOI 10.1007/s00125-019-4831-3
4. Clinical Evidence for Targeting NAD Therapeutically.
   Radenkovic D, Reason, Verdin E. · · 2020 · cited 45× · PMID 32942582 · DOI 10.3390/ph13090247
5. Impact of NAD+ metabolism on ovarian aging.
   Liang J, Huang F, Song Z, Tang R, et al · · 2023 · cited 30× · PMID 38041117 · DOI 10.1186/s12979-023-00398-w
6. NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults.
   Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, et al · · 2021 · cited 26× · PMID 34191033 · DOI 10.1093/jn/nxab193
7. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications.
   Banerjee P, Olmsted-Davis EA, Deswal A, Nguyen MT, et al · · 2022 · cited 8× · PMID 35801078 · DOI 10.20517/jca.2022.13