Who is sponsoring NCT03309683?

NCT03309683 is sponsored by Radboud University Medical Center.

What drugs are being tested in NCT03309683?

Interventions in NCT03309683: Olympus Quick Clip Pro - Single Use Repositionable Clips.

What condition does NCT03309683 study?

NCT03309683 studies Polyp, Colonic, Bleeding.

Is NCT03309683 still recruiting?

NCT03309683 is currently completed. Last updated 30 March 2023.

Last reviewed 2023-03-30 · How we verify

NCT03309683: CLIPPER

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clip Placement Following Colonic Endoscopic Mucosal Resection (EMR)

Completed NA Last updated 30 March 2023

What this trial tests

NA trial testing Olympus Quick Clip Pro - Single Use Repositionable Clips in Polyp, Colonic in 356 participants. Completed in 1 March 2023.

Timeline

5 March 2018

Primary endpoint
19 August 2022

1 March 2023

Quick facts

Lead sponsor	Radboud University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	356
Start date	5 March 2018
Primary completion	19 August 2022
Estimated completion	1 March 2023
Sites	2 locations across Netherlands

Drugs / interventions tested

Olympus Quick Clip Pro - Single Use Repositionable Clips

Conditions studied

Polyp, Colonic — all drugs for Polyp, Colonic →
Bleeding — all drugs for Bleeding →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Polyp, Colonic or Bleeding. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study design: A national, multi-center, patient-blinded, randomized clinical trial. Study population: Patients undergoing EMR with a moderate to severe risk (right sided colon, ≥2cm) of developing Delayed Bleeding (DB). Intervention: PC will be compared to standard care (no PC). Main study endpoints: Primary endpoint is the incidence of DB. Secondary endpoints are cost-effectiveness, quality of life and (severe) adverse events related to PC, adenoma recurrence and risk factors for DB.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial.
Turan AS, Moons LMG, Schreuder RM, Schoon EJ, et al · · 2021 · cited 9× · PMID 33461579 · DOI 10.1186/s13063-020-04996-7
The effect of prophylactic clipping on delayed bleeding after proximal colonic endoscopic mucosal resection: a multicenter, randomized controlled trial (CLIPPER).
Kemper G, Turan AS, Schreuder RM, Schrauwen RWM, et al · · 2025 · cited 3× · PMID 40695477 · DOI 10.1055/a-2637-3180
· 2023 · PMID 36269666 · DOI 10.1002/ueg2.12321

Verify or expand the search:

Other Radboud University Medical Center trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03309683 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
Last refreshed: 30 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03309683.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing