Paracetamol Metabolism Research in Postoperative Hepatic Surgery (PARAFOI)

NCT03297073 NA COMPLETED

The main objective of this study was to evaluate the 5-day kinetics of plasma paracetamol levels in postoperative major hepatic surgery (resection greater than or equal to three hepatic segments) compared with less extensive liver resection and hepatic re-intervention. The clearance of indocyanine green is a marker of hepatic perfusion but also of the proper hepatocyte functioning, if hemodynamic conditions are stable. Some patients may be operated on up to four or five times in the liver. Moreover, these patients probably present an increased risk of postoperative hepatocellular insufficiency due to a quantitative and qualitative decrease in their hepatic parenchyma. It is therefore interesting to evaluate the use of paracetamol in this situation.

Details

Lead sponsor	University Hospital, Lille
Phase	NA
Status	COMPLETED
Enrolment	90
Start date	2016-11-20
Completion	2019-11

Conditions

• Paracetamol Causing Adverse Effects in Therapeutic Use
• Hepatic Disease

Interventions

• paracetamol
• hepatic surgery

Primary outcomes

• Dosing and kinetics of paracetamolemia — during the 5 post-operative days
  this determination of the plasma paracetamol dosage on D0 (H6: 6 hours after the end of the procedure) and D1 D2 D3 D4 D5 (samples taken at 6 am each day just before the injection of paracetamol whose administration hours will be 6h 12h 18h and midnight)

Countries

France