Last reviewed · How we verify
NCT03296189: LASTE
Local Anaesthetic and Steroid in the Ureter
NA trial testing Levobupivacaine in Pain, Postoperative in 150 participants. Status unknown.
1 December 2019
Quick facts
| Lead sponsor | The Adelaide and Meath Hospital, incorporating The National Children's Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 150 |
| Start date | 1 November 2018 |
| Primary completion | 1 December 2019 |
| Estimated completion | 31 December 2019 |
| Sites | 1 location across Ireland |
Drugs / interventions tested
- Levobupivacaine (LEVOBUPIVACAINE) — full drug profile →
- Dexamethasone Sodium Phosphate (dexamethasone phosphate) — full drug profile →
- Placebos — full drug profile →
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Ureter Stone — all drugs for Ureter Stone →
Sponsor
The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Who can join
18 and older, any sex, with Pain, Postoperative or Ureter Stone. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Précis: Randomised control trial to evaluate safety and efficacy of intraluminal injection of high pH-high concentration of a long-acting local anesthetic and long-acting glucocorticoid in the ureter after ureteroscopy. Objectives: To evaluate a novel method to ameliorate post-ureteroscopy pain in all patients (with and without stents) Endpoints: Primary endpoint: mean visual analog pain scale (VAS) post-operatively starting at 1 hour, 4 hours, 8 hours, 24 hours and 7 days post-procedure (minimum of 3 VAS scores). VAS pain, ureteral stent symptoms and analgesic requirement will be assessed at different points during this time period. Secondary endpoint: Postoperative Nausea/Vomiting (PONV), safety of intraluminal injection of high concentration alkalinized local anaesthetic solution by comparing adverse events between placebo and treatment arms. In addition, rehospitalisation rates and postoperative length of stay will be compared between the three groups. Population: 150 adult patients undergoing ureteroscopy for ureteric stone disease stratified into negative ureteroscopy and those treated for a stone with or without stent insertion postoperatively Number of Sites: Tallaght Hospital Study Duration: 8 months
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03296189
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Levobupivacaine
Trials testing the same drug.
- NCT06695468 — Efficacy and Safety of Adding Dexmedetomidine to Levobupivacaine in Rectus Sheath Block Compared to Quadratus Lumborum B · Phase 4 · not yet recruiting
- NCT06410404 — Dexmeditomedine as an Adjuvant to Levobupivacaine in Transversus Thoracis Plane Block on the Management of Post-sternoto · NA · not yet recruiting
- NCT06011746 — Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy · Phase 4 · completed
- NCT05877131 — Evaluate Efficacy Levobupivacaine 0.125% Versuss Ropivacaine 0.2% in Hemodynamic Alterations in Labor and Fetal Repercus · Phase 4 · unknown
- NCT05600296 — Ultrasound-guided Ilioinguinal/Iliohypogastric Nerve Block Compared to the Combined Therapy With Spermatic Cord Block · Phase 1 · completed
Other recruiting trials for Pain, Postoperative
Currently open trials in the same condition.
- NCT07512141 — Single Versus Double Drains in the Axillary and Pectoral Regions After Modified Radical Mastectomy · NA · recruiting
- NCT07354581 — Erector Spinae Plane Block vs Quadro-Iliac Plane Block After Lumbar Instrumentation Surgery · NA · recruiting
- NCT07239817 — PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach · NA · recruiting
- NCT06740214 — Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty · Phase 3 · recruiting
- NCT07057557 — Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites · NA · recruiting
Other The Adelaide and Meath Hospital, incorporating The National Children's Hospital trials
Trials by the same sponsor.
- NCT03306238 — LAParoscopic Entry Technique in REnal Surgery · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03296189 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Adelaide and Meath Hospital, incorporating The National Children's Hospital
- Last refreshed: 17 January 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03296189.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing